STRUCTURE‐SEQUENCE FEATURES BASED PREDICTION OF PHOSPHOSITES OF SERINE/THREONINE PROTEIN KINASES OF M. TUBERCULOSIS

Abstract Elucidation of signalling events in a pathogen is potentially important to tackle the infection caused by it. Such events...

PROTEIN TERTIARY STRUCTURE PREDICTION AND REFINEMENT USING DEEP LEARNING AND ROSETTA IN CASP14

Abstract The trRosetta structure prediction method employs deep learning to generate predicted residue-residue distance and orientation...

 
 
 

PROTEIN STRUCTURE PREDICTION USING DEEP LEARNING DISTANCE AND HYDROGEN‐BONDING RESTRAINTS IN CASP14

ABSTRACT In this article, we report 3D structure prediction results by two of our best server groups in CASP14. These two servers were...

MOLECULAR DYNAMICS SIMULATIONS REVEAL THE DISRUPTION MECHANISM OF A 2,4‐THIAZOLIDINEDIONE DERIVATIVE C30 AGAINST TAU HEXAPEPTIDE OLIGOMER

Abstract 2,4-thiazolidinedione derivatives have been reported to inhibit the aggregation of tau protein, in which compound 30 can not...

 
 
 

EXOMETABOLOME PROFILING REVEALS ACTIVATION OF THE CARNITINE BUFFERING PATHWAY IN FED‐BATCH CULTURES OF CHO CELLS CO‐FED WITH GLUCOSE AND LACTIC ACID

Abstract Adjustments to CHO cell physiology were recently observed during implementation of a Raman spectroscopy-based glucose and...

LABOUR‐SAVING CONSTRUCTION OF A TARGET PROTEIN INTERACTION NETWORK BY SELECTIVE CULTURE AND HIGH‐THROUGHPUT SEQUENCING

Abstract Background : Yeast two-hybrid is a classic method of screening for protein-protein interactions. However, the operation process...

 
 
 

ENGINEERING CHLOROPLAST DEVELOPMENT IN RICE THROUGH CELL‐SPECIFIC CONTROL OF ENDOGENOUS GENETIC CIRCUITS

Summary The engineering of C 4 photosynthetic activity into the C 3 plant rice has the potential to nearly double rice yields. To engineer...

ASSESSMENT OF PROTEIN MODEL STRUCTURE ACCURACY ESTIMATION IN CASP14: OLD AND NEW CHALLENGES

Abstract In CASP, blind testing of model accuracy estimation methods has been conducted on models submitted by tertiary structure prediction...

 
 
 

PROTEIN OLIGOMER MODELING GUIDED BY PREDICTED INTER‐CHAIN CONTACTS IN CASP14

Abstract For CASP14, we developed deep learning-based methods for predicting homo-oligomeric and hetero-oligomeric contacts and used...

MODELLING OF GENE LOSS PROPENSITY IN THE PANGENOMES OF THREE BRASSICA SPECIES SUGGESTS DIFFERENT MECHANISMS BETWEEN POLYPLOIDS AND DIPLOIDS

Summary Plant genomes demonstrate significant presence/absence variation within a species, however the factors that lead to this variation...

 
 
 

CRISPR‐CEREAL: A GUIDE RNA DESIGN TOOL INTEGRATING REGULOME AND GENOMIC VARIATION FOR WHEAT, MAIZE AND RICE

Abstract The clustered regularly interspaced short palindromic repeat -associated protein genome editing system is revolutionizing...

INTRODUCTION OF A NEW SCHEME FOR CLASSIFYING Β‐TURNS IN PROTEIN STRUCTURES

Abstract Protein β-turn classification remains an area of ongoing development in structural biology research. While the commonly used...

 
 
 
Issue Information

ISSUE INFORMATION

The Artemisia annua TCP transcription factor AaTCP15 is a new regulator promoting artemisinin biosynthesis in responding to JA and...

MICROFLUIDIC CHIP‐BASED SINGLE‐CELL CLONING TO ACCELERATE BIOLOGIC PRODUCTION TIMELINES

Abstract Cell line development represents a critical, yet time-consuming step in the biomanufacturing process as significant resources...

 
 
 

AN ENGINEERED MICROFLUIDIC BLOOD‐BRAIN BARRIER MODEL TO EVALUATE THE ANTI‐METASTATIC ACTIVITY OF Β‐BOSWELLIC ACID

Abstract Background The development of anti-cancer drugs with the ability to inhibit brain metastasis through the blood-brain barrier...

DYNAMICS IN AN UNUSUAL ACYL CARRIER PROTEIN FROM A LADDERANE LIPID‐SYNTHESIZING ORGANISM

Abstract Anaerobic ammonium-oxidizing bacteria express a distinct acyl carrier protein implicated in the biosynthesis of the highly...

 
 
 

BENCHMARKING OF STRUCTURE REFINEMENT METHODS FOR PROTEIN COMPLEX MODELS

Abstract Protein structure docking is the process in which the quaternary structure of a protein complex is predicted from individual...

THE DENATURED STATE OF HIV‐1 PROTEASE UNDER NATIVE CONDITIONS

Abstract The denatured state of several proteins has been shown to display transient structures that are relevant for folding, stability...

 
 
 

HISTIDINE PROTONATION STATES ARE KEY IN THE LIGI CATALYTIC REACTION MECHANISM

Abstract Lignin is one of the world's most abundant organic polymers, and 2-pyrone-4,6-dicarboxylate lactonase catalyzes the hydrolysis...

IN SILICO PROCESS CHARACTERIZATION FOR BIOPHARMACEUTICAL DEVELOPMENT FOLLOWING THE QUALITY BY DESIGN CONCEPT

Abstract With the Quality by Design initiative, regulatory authorities demand a consistent drug quality originating from a well-understood...

 
 
 



World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

MicroRNA-17-5p Promotes Cardiac Hypertrophy by Targeting Mfn2 to Inhibit...

Abstract Pathological cardiac hypertrophy is the leading cause of heart failure, and miRNAs have been recognized as key factors in cardiac hypertrophy. This study aimed to... Read more ...

Scientist, Hematologic and Immunologic Toxicology - La Jolla, CA - Johnson &...

As part of the cutting-edge Global Predictive, Investigative and Translational Toxicology Team, the candidate will have the opportunity to work within...From Johnson & Johnson... Read more ...

Bringing Protection Back in Line

Bringing Protection Back in Line

Research refines platform to address immune disorders Dr. Esma Yolcu and Dr. Haval Shirwan, Co-pioneers of ProtEx technology By Davis Suppes | Bond LSC The things that protect... Read more ...

After 40 Years, HIV Presents Research Problems New and Old

After 40 Years, HIV Presents Research Problems New and Old

In the years since AIDS was first described in medical research, the scientific map of that disease has changed enormously. Once it was relatively empty. Now scientists... Read more ...

Exosomal circRNA HIPK3 knockdown inhibited cell proliferation and metastasis...

Abstract Prostate cancer is the second frequent malignancy among men in the world. Exosomal circular RNAs have been reported to function in PCa progression. The current study... Read more ...

Prognostic value and immunological characteristics of a novel...

Abstract Autophagy affects the development, progression, and prognosis of various cancers including pancreatic cancer. To develop an autophagy-related prognostic model of... Read more ...

Chiral nanomaterials for tumor therapy: autophagy, apoptosis, and...

Chirality is a fundamental characteristic of natural molecules and a crucial factor in the biochemical reactions of living cells and organisms. Recently, researchers have... Read more ...

Ramil the snow leopard tests positive for COVID at the San Diego Zoo

Zoo staff say the animal's symptoms are mild and are still investigating how he got infected Read more ...

Enhanced lignin biodegradation by consortium of white rot fungi: microbial...

As one of the major components of lignocellulosic biomass, lignin has been considered as the most abundant renewable aromatic feedstock in the world. Comparing with thermal or... Read more ...

Design and heterologous expression of a novel dimeric LL37 variant in Pichia...

The antimicrobial peptide LL37 is produced by white blood cells and various epithelial cells, and has the outstanding advantages of participating in immune regulation, causing... Read more ...