Genes / Protein / Bioinformatic / Bioinformatics / Gene

Expression of B lymphocyte-induced maturation protein 1 in keratinocyte and cytokine signalling drives human Th17 response in psoriasis

Posted On: Mar 21, 2023   |   Posted By: Springer

Abstract
Transcriptional factor B lymphocyte-induced maturation protein 1 is pivotally implicated in T helper 17 cell differentiation. This study investigated expression of the Blimp-1 protein, positive regulatory domain 1 , and cytokine genes in psoriasis. Affected and non-affected skin samples were used to assess gene and protein expressions by reverse transcription-quantitative PCR , and immunostaining and confocal microscopy, respectively; the normalised public transcriptomic data permitted differential gene expression analyses. On RT-qPCR, PRDM1 and IL17A transcripts showed higher expression in AS-PsO than in nAS-PsO. Confocal microscopy showed Blimp-1 protein expression in epidermal layer keratinocytes in AS-PsO, but not in nAS-PsO. Bioinformatic analysis of the transcriptomic dataset GSE13355 corroborated the increased PRDM1 , signal transducer and activator of transcription 3 , IL12B...

Continue reading ...

 






The last Posts from Springer



World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Director of Bioinformatics - Nautilus Bio - San Diego, CA

You are fluent in a wide variety of statistical analysis skills, data processing and visualization approaches, programming languages and environments,... Read more ...

Scientist, Immunoassay Development - TRAQ Inc. - Carlsbad, CA

Demonstrated proficiency in the design of experiments with statistical analysis of data. Document experimental data, presenting data, conclusions, and... $75,000... Read more ...

Exosomal Lnc NEAT1 from endothelial cells promote bone regeneration by...

Bone regeneration is a complex procedure that involves an interaction between osteogenesis and inflammation. Macrophages in the microenvironment are instrumental in bone... Read more ...

Analytical methods for assessing antimicrobial activity of nanomaterials in...

Assessing the antimicrobial activity of engineered nanomaterials , especially in realistic scenarios, is of great significance for both basic research and applications... Read more ...

Theranostic applications of selenium nanomedicines against lung cancer

The incidence and mortality rates of lung cancer are among the highest in the world. Traditional treatment methods include surgery, chemotherapy, and radiotherapy. Although... Read more ...

Alternative splicing: a new breakthrough for understanding tumorigenesis and...

Abstract Background Alternative splicing is a post-transcriptional process that produces transcript variants, thus leading to transcriptome complexity. Recently, the scope of... Read more ...

How an Electrical Engineer Solved Australia's Most Famous Cold Case

Dead, and in a jacket and tie. That's how he was on 1 December 1948 , when two men found him slumped against a retaining wall on the beach at Somerton, a suburb of Adelaide... Read more ...

Stress test kit could boost koala joey survival

Mortality rates of orphaned koala joeys could be greatly reduced by a non-invasive stress test kit being trialed by University of Queensland researchers. Read more ...

A sowing, pruning, and harvesting robot for Synecoculture farming

Synecoculture is a new agricultural method advocated by Dr. Masatoshi Funabashi, senior researcher at Sony Computer Science Laboratories, Inc. , in which various kinds of... Read more ...

'Super seaweed' produces natural health compounds and medicine from the sea

Researchers from Tel Aviv University and the Israel Oceanographic and Limnological Research Institute have succeeded in significantly increasing the ability of seaweed to... Read more ...