PEPPRO: QUALITY CONTROL AND PROCESSING OF NASCENT RNA PROFILING DATA

Nascent RNA profiling is growing in popularity; however, there is no standard analysis pipeline to uniformly process the data and assess...

MULTI-OMIC PROFILING OF LUNG AND LIVER TUMOR MICROENVIRONMENTS OF METASTATIC PANCREATIC CANCER REVEALS SITE-SPECIFIC IMMUNE REGULATORY PATHWAYS

The majority of pancreatic ductal adenocarcinomas are diagnosed at the metastatic stage, and standard therapies have limited activity...

 
 
 

SUPER-RESOLUTION VISUALIZATION AND MODELING OF HUMAN CHROMOSOMAL REGIONS REVEALS COHESIN-DEPENDENT LOOP STRUCTURES

The 3D organization of the chromatin fiber in cell nuclei plays a key role in the regulation of gene expression. Genome-wide techniques...

CELLULAR AND TRANSCRIPTOMIC ANALYSES REVEAL TWO-STAGED CHLOROPLAST BIOGENESIS UNDERPINNING PHOTOSYNTHESIS BUILD-UP IN THE WHEAT LEAF

The developmental gradient in monocot leaves has been exploited to uncover leaf developmental gene expression programs and chloroplast...

 
 
 

ON THE OPTIMISTIC PERFORMANCE EVALUATION OF NEWLY INTRODUCED BIOINFORMATIC METHODS

Most research articles presenting new data analysis methods claim that “the new method performs better than existing methods,” but...

NOVEL PREDICTIONS ARISE FROM CONTRADICTIONS

 
 
 

FUNCTIONAL MAPPING OF ANDROGEN RECEPTOR ENHANCER ACTIVITY

Androgen receptor is critical to the initiation, growth, and progression of prostate cancer. Once activated, the AR binds to cis-regulatory...

HDAC4 DEGRADATION DURING SENESCENCE UNLEASHES AN EPIGENETIC PROGRAM DRIVEN BY AP-1/P300 AT SELECTED ENHANCERS AND SUPER-ENHANCERS

Cellular senescence is a permanent state of replicative arrest defined by a specific pattern of gene expression. The epigenome in senescent...

 
 
 

SPATIALDWLS: ACCURATE DECONVOLUTION OF SPATIAL TRANSCRIPTOMIC DATA

Recent development of spatial transcriptomic technologies has made it possible to characterize cellular heterogeneity with spatial...

LONG-READ CDNA SEQUENCING IDENTIFIES FUNCTIONAL PSEUDOGENES IN THE HUMAN TRANSCRIPTOME

Pseudogenes are gene copies presumed to mainly be functionless relics of evolution due to acquired deleterious mutations or transcriptional...

 
 
 

ENDOGENOUS RETROVIRUSES IN THE ORIGINS AND TREATMENT OF CANCER

Endogenous retroviruses are emerging as promising therapeutic targets in cancer. As remnants of ancient retroviral infections, ERV-derived...

THE GENETIC MECHANISM OF HETEROSIS UTILIZATION IN MAIZE IMPROVEMENT

In maize hybrid breeding, complementary pools of parental lines with reshuffled genetic variants are established for superior hybrid...

 
 
 

PROMOTER G-QUADRUPLEX FOLDING PRECEDES TRANSCRIPTION AND IS CONTROLLED BY CHROMATIN

Four-stranded G-quadruplexes are DNA secondary structures in the human genome that are primarily found in active promoters associated...

SCSNV: ACCURATE DSCRNA-SEQ SNV CO-EXPRESSION ANALYSIS USING DUPLICATE TAG COLLAPSING

Identifying single nucleotide variants has become common practice for droplet-based single-cell RNA-seq experiments; however, presently,...

 
 
 

LIMITED HAPLOTYPE DIVERSITY UNDERLIES POLYGENIC TRAIT ARCHITECTURE ACROSS 70 YEARS OF WHEAT BREEDING

Selection has dramatically shaped genetic and phenotypic variation in bread wheat. We can assess the genomic basis of historical phenotypic...

GENETIC AND ENVIRONMENTAL MODULATION OF TRANSPOSITION SHAPES THE EVOLUTIONARY POTENTIAL OF ARABIDOPSIS THALIANA

How species can adapt to abrupt environmental changes, particularly in the absence of standing genetic variation, is poorly understood...

 
 
 

DETERMINATION OF COMPLETE CHROMOSOMAL HAPLOTYPES BY BULK DNA SEQUENCING

Haplotype phase represents the collective genetic variation between homologous chromosomes and is an essential feature of non-haploid...

EMBRYO CHH HYPERMETHYLATION IS MEDIATED BY RDDM AND IS AUTONOMOUSLY DIRECTED IN BRASSICA RAPA

RNA-directed DNA methylation initiates cytosine methylation in all contexts and maintains asymmetric CHH methylation. Mature plant...

 
 
 

TRANSGENERATIONAL EFFECT OF MUTANTS IN THE RNA-DIRECTED DNA METHYLATION PATHWAY ON THE TRIPLOID BLOCK IN ARABIDOPSIS

Hybridization of plants that differ in number of chromosome sets frequently causes endosperm failure and seed arrest, a phenomenon...

ROLE OF EPIGENETICS IN UNICELLULAR TO MULTICELLULAR TRANSITION IN DICTYOSTELIUM

The evolution of multicellularity is a critical event that remains incompletely understood. We use the social amoeba, Dictyostelium...

 
 
 



World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

PEPPRO: quality control and processing of nascent RNA profiling data

Nascent RNA profiling is growing in popularity; however, there is no standard analysis pipeline to uniformly process the data and assess quality. Here, we introduce PEPPRO, a... Read more ...

Enhanced cercosporin production by co-culturing Cercospora sp. JNU001 with...

Owing to the excellent properties of photosensitization, cercosporin, one of naturally occurring perylenequinonoid pigments, has been widely used in photodynamic therapy, or as... Read more ...

IAmScience Kulbir Sandhu

IAmScience Kulbir Sandhu

By Lauren Hines | Bond LSC Kulbir Sandhu's curiosity had guided him from place to place, but it was his fascination with plant science that has stayed the same. While Sandhu... Read more ...

Epigenetic changes drive the fate of a B cell

B cells are the immune cells responsible for creating antibodies, and most produce antibodies in response to a pathogen or a vaccine. A small subset of B cells instead... Read more ...

Identifying collateral and synthetic lethal vulnerabilities within the...

A pair of genes is defined as synthetically lethal if defects on both cause the death of the cell but a defect in only one of the two is compatible with cell viability... Read more ...

Scientist - Emergent Biosolutions - San Diego, CA

The Scientist position supports the R&D teams to achieve company pipeline objectives by conducting research assignments involving a variety of laboratory...From Emergent... Read more ...

SSBER: removing batch effect for single-cell RNA sequencing data

With the continuous maturity of sequencing technology, different laboratories or different sequencing platforms have generated a large amount of single-cell transcriptome... Read more ...

Antimalarial Drug Resistance and Implications for the WHO Global Technical...

Abstract Purpose of Review Five years have passed since the World Health Organization released its Global Technical Strategy for Malaria. In that time, progress against malaria... Read more ...

Chloroplast genome analysis of Angiosperms and phylogenetic relationships...

Abstract Availability of comprehensive phylogenetic tree for flowering plants which includes many of the economically important crops and trees is one of the essential... Read more ...

Sr. Custom Applications Scientist - BD - San Diego, CA

Advanced design and development of assays including flow cytometry assays for assessment of cellular response to changes in the normal physiological make-up.From BD - Sat, 15... Read more ...