Enzymes

Increasing sputum levels of gamma-glutamyltransferase may identify cystic fibrosis patients who do not benefit from inhaled glutathione

4 years ago   |   By ScienceDirect

Publication date: Available online 14 December 2016

Author(s): Alessandro Corti, Matthias Griese, Andreas Hector, Alfonso Pompella
Glutathione is decreased in cystic fibrosis airways, thus its resupply by inhalation has been employed to restore antioxidant defense. CF airways present however increased activity of gamma-glutamyltransferase , the enzyme specifically capable of degrading GSH, and thus inhaled GSH might be promptly catabolized. In addition, prooxidant reactions are known to originate during GGT-mediated GSH catabolism. We determined levels of GGT in the sputum samples...
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The psychometric properties of the Leicester Cough Questionnaire and Respiratory Symptoms in CF tool in cystic fibrosis: A preliminary study

4 years ago   |   By ScienceDirect

Publication date: Available online 14 December 2016

Author(s): Nathan Ward, Kathy Stiller, Hilary Rowe, Anne E Holland
Background There are few tools to quantify the impact of cough in cystic fibrosis . The psychometric properties of the Leicester Cough Questionnaire and Respiratory Symptoms in CF tool were investigated in adults with CF. Methods Validity and reliability were assessed in clinically stable participants who completed the questionnaires twice, along with the Cystic Fibrosis Questionnaire - Revised . Responsiveness was assessed by change in questionnaires following treatment...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Enhanced Vitamin E content in an Indica rice cultivar harbouring two...

Abstract Micronutrient deficiency results in malnutrition, which is prevalent all over the world and may lead to premature death in women and children. Strategies formulated... Read more ...

BED domain‐containing NLR from wild barley confers resistance to leaf rust

Summary Leaf rust, caused by Puccinia hordei, is a devastating fungal disease affecting barley production globally. Despite the effectiveness of genetic resistance, the... Read more ...

The OsmiRNA166b‐OsHox32 pair regulates mechanical strength of rice plants by...

Summary The plant cell wall provides mechanical strength to support plant growth and development and to determine plant architecture. Cellulose and mixed‐linkage glucan present... Read more ...

Seeing is believing: a visualization toolbox to enhance selection efficiency...

Abstract The emerging and promising biotechnology methodology of CRISPR/Cas9 gene‐editing is revolutionizing crop improvement. However, the low‐efficiency, time‐consuming, and... Read more ...

Developing a Nicotiana benthamiana transgenic platform for high‐value...

Summary To engineer Nicotiana benthamiana to produce novel diterpenoids, we first aimed to increase production of the diterpenoid precursor geranylgeranyl pyrophosphate by... Read more ...

Generation of novel self‐incompatible Brassica napus by CRISPR/Cas9

Abstract Self‐incompatibility is a genetic mechanism that prevents inbreeding in hermaphrodite angiosperms via the rejection of self‐pollen. SI lines facilitate the utilization... Read more ...

Advanced domestication: harnessing the precision of gene editing in crop...

Summary Human population growth has increased the demand for food crops, animal feed, biofuel and biomaterials, all the while climate change is impacting environmental growth... Read more ...

Long‐range assembly of sequences helps to unravel the genome structure and...

Summary Genomics studies in wild species of wheat have been limited due to the lack of references; however, new technologies and bioinformatics tools have much potential to... Read more ...

The role of VvMYBA2r and VvMYBA2w alleles of the MYBA2 locus in the...

Summary In grape, MYBA1 and MYBA2 at the colour locus are the major genetic determinants of grape skin colour, and the mutation of two functional genes from these loci leads to... Read more ...

A transposon in the vacuolar sorting receptor gene TaVSR1‐B promoter region...

Abstract Root depth, as an important component of root architecture, plays a significant role in growth, grain yield determination and abiotic stress tolerance in crop plants... Read more ...