Applied

Resolving single-cell heterogeneity from hundreds of thousands of cells through sequential hybrid clustering and NMF

2 monthes ago   |   By Oxford Journals

AbstractMotivationThe rapid proliferation of single-cell RNA-Sequencing technologies has spurred the development of diverse computational approaches to detect transcriptionally coherent populations. While the complexity of the algorithms for detecting heterogeneity has increased, most require significant user-tuning, are heavily reliant on dimension reduction techniques and are not scalable to ultra-large datasets. We previously described a multi-step algorithm, Iterative Clustering and Guide-gene selection , which applies intra-gene correlation and hybrid clustering to uniquely resolve...
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