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Pacific Biosciences

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SEQUENCING 101: VIDEO INTRODUCTION TO PACBIO SEQUENCING AND THE SEQUEL II SYSTEM

We're pleased to release a short video describing PacBio Sequencing and our latest platform, the Sequel II System. If you've ever wondered...

HiCanu for HiFi Reads Produces First Assembly of Human Segmental Duplications and Centromeres

HICANU FOR HIFI READS PRODUCES FIRST ASSEMBLY OF HUMAN SEGMENTAL DUPLICATIONS AND CENTROMERES

In a new preprint , scientists from the National Human Genome Research Institute, the University of Washington, and other institutions...

 
 
 
Sequencing 101: The Evolution of DNA Sequencing Tools

SEQUENCING 101: THE EVOLUTION OF DNA SEQUENCING TOOLS

Welcome to the Sequencing 101 blog series - where we will provide introductions to sequencing technology, genomics, and much more! If...

AGBT 2020 Highlights: Reference-Grade Assemblies, Iso-Seq Data, and More

AGBT 2020 HIGHLIGHTS: REFERENCE-GRADE ASSEMBLIES, ISO-SEQ DATA, AND MORE

It was a pleasure to attend the annual Advances in Genome Biology & Technology meeting in sunny Marco Island, Fla., last month. The...

 
 
 
Prokaryotic Methylation Detection on the Sequel II System

PROKARYOTIC METHYLATION DETECTION ON THE SEQUEL II SYSTEM

Since the first PacBio instrument was released in 2011, methylation detection has been one of the advantages of SMRT Sequencing. The...

A Menagerie of New Genomes Released by International Ensembl Project

A MENAGERIE OF NEW GENOMES RELEASED BY INTERNATIONAL ENSEMBL PROJECT

The new and updated species in Ensembl 99 from the Vertebrate Genomes Project Meerkats, yaks, geese, and lots of flies - oh my! A...

 
 
 
SMRT Grant Winners: Three Scientists Selected to Use HiFi Sequencing to Tackle Genomic Challenges

SMRT GRANT WINNERS: THREE SCIENTISTS SELECTED TO USE HIFI SEQUENCING TO TACKLE GENOMIC CHALLENGES

PacBio highly accurate long reads, known as HiFi reads , offer all the benefits of long-read sequencing with accuracy comparable to...

Beyond Contiguity - Assessing the Quality of Genome Assemblies with the 3 C's

BEYOND CONTIGUITY - ASSESSING THE QUALITY OF GENOME ASSEMBLIES WITH THE 3 C'S

With high-throughput long-read sequencing, it is now affordable and routine to produce a de novo genome assembly for microbes, plants...

 
 
 
Nice to See You, Telomere: Scientists Use SMRT Sequencing for Previously Intractable Regions of the Human Genome

NICE TO SEE YOU, TELOMERE: SCIENTISTS USE SMRT SEQUENCING FOR PREVIOUSLY INTRACTABLE REGIONS OF THE HUMAN GENOME

Diagram depicting telomere shortening. Telomeres and centromeres have long vexed genomic scientists. In the early days of genome sequencing,...

A Rare Opportunity to Help Tackle Daughter's Rare Disease

A RARE OPPORTUNITY TO HELP TACKLE DAUGHTER'S RARE DISEASE

The rarest day on the calendar is February 29th - which makes it the perfect time to celebrate Rare Disease Day. On this day, we join...

 
 
 
A Rose is a Rose: HiFi Reads Enable Sequencing of Complex Tetraploid Species

A ROSE IS A ROSE: HIFI READS ENABLE SEQUENCING OF COMPLEX TETRAPLOID SPECIES

Assembling the genomes of the tetraploid rose has been challenging, but PacBio HiFi reads are helping Dutch researchers overcome the...

NARMS Scientists Track Antibiotic Resistance in Foodborne Bacteria Using SMRT Sequencing

NARMS SCIENTISTS TRACK ANTIBIOTIC RESISTANCE IN FOODBORNE BACTERIA USING SMRT SEQUENCING

Launched in 1996, NARMS is a U. S. public health surveillance system that tracks antimicrobial susceptibility of select foodborne enteric...

 
 
 
PacBio Sequencing Contributes to New Japanese Reference Genome

PACBIO SEQUENCING CONTRIBUTES TO NEW JAPANESE REFERENCE GENOME

People of Japanese descent just moved a little closer toward the promise of precision medicine thanks to a population-specific reference...

‘Pathway for Discovery': SMRT Grant Winner Aims to Address the Mysteries of Autism with HiFi Sequencing

‘PATHWAY FOR DISCOVERY': SMRT GRANT WINNER AIMS TO ADDRESS THE MYSTERIES OF AUTISM WITH HIFI SEQUENCING

Tychele Turner, Assistant Professor, Washington University in St. Louis School of Medicine We are pleased to announce the winner of...

 
 
 
At PAG 2020, HiFi Data ‘Transformational' for Advancing Plant and Animal Research

AT PAG 2020, HIFI DATA ‘TRANSFORMATIONAL' FOR ADVANCING PLANT AND ANIMAL RESEARCH

What better way to start the year than a gathering of thousands of stellar scientists? We were excited, once again, to attend the Plant...

When Snakes Strike: SMRT Sequencing Reveals Hidden “Venom-ome”

WHEN SNAKES STRIKE: SMRT SEQUENCING REVEALS HIDDEN “VENOM-OME”

A team of scientists from SciGenom Research Foundation in India has assembled the genome and transcriptome of the lethal Indian Cobra...

 
 
 
Project to Rapidly Sequence Maize Pangenome Delivers Publicly Available Resource

PROJECT TO RAPIDLY SEQUENCE MAIZE PANGENOME DELIVERS PUBLICLY AVAILABLE RESOURCE

Matt Hufford, associate professor at Iowa State University, helped produce a 26-line maize pangenome assembly collection Maize researchers...

Direct Phased Genome Assembly Using Nighthawk on HiFi Reads

DIRECT PHASED GENOME ASSEMBLY USING NIGHTHAWK ON HIFI READS

By Zev Kronenberg, Senior Engineer of Bioinformatics at PacBio Since the introduction of HiFi reads the community has embraced these...

 
 
 
SMRT Grant Winner: Hunting for Answers in Spinocerebellar Ataxia

SMRT GRANT WINNER: HUNTING FOR ANSWERS IN SPINOCEREBELLAR ATAXIA

Cleo van Diemen, University Medical Center Groningen A hearty congratulations to Cleo van Diemen at the University Medical Center Groningen...

Novel Workflow Produces Fully Phased Human Genome Assemblies Without Trio Sequencing

NOVEL WORKFLOW PRODUCES FULLY PHASED HUMAN GENOME ASSEMBLIES WITHOUT TRIO SEQUENCING

A new preprint from lead authors David Porubsky and Peter Ebert, senior authors Evan Eichler and Tobias Marschall , and collaborators...

 
 
 



World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Convalescent Plasma: A Therapy for COVID-19?

Convalescent Plasma: A Therapy for COVID-19?

To develop a treatment for patients with COVID-19, researchers around the world are steadfastly exploring numerous angles, including testing existing antiviral drugs and new... Read more ...

Inovio Begins Experimental COVID-19 Vaccine Tests in Healthy Volunteers

Inovio Begins Experimental COVID-19 Vaccine Tests in Healthy Volunteers

Inovio Pharmaceuticals, one of the biotechs developing a vaccine to prevent COVID-19, has received the FDA's OK to start testing its candidate in healthy volunteers. The... Read more ...

Sage Restructuring Halves Staff, Turns Focus to Failed Depression Drug

Sage Restructuring Halves Staff, Turns Focus to Failed Depression Drug

Sage Therapeutics is cutting workers who sell its only commercialized drug in a corporate reorganization that it says allows it to focus on clinical-stage compounds, including... Read more ...

Creating Consistent Value in Biotech Without Diluting Stakeholders

Creating Consistent Value in Biotech Without Diluting Stakeholders

One of the greatest challenges for pre-commercial biotech companies is consistently generating capital necessary for operating costs and for R&D of new products that provide... Read more ...

Interactive, Online Xcelerating Life Sciences Boston Event Set for May 13

Interactive, Online Xcelerating Life Sciences Boston Event Set for May 13

In the Boston biotech hub, much progress has been made advancing digital health, but significant scientific, technological, financial, and regulatory challenges remain. Join us... Read more ...

Millendo May Restructure After Prader-Willi Drug Fails Pivotal Test

Millendo May Restructure After Prader-Willi Drug Fails Pivotal Test

Millendo Therapeutics is considering a corporate reorganization after its lead drug, an investigational treatment for a rare genetic condition characterized by unrelenting... Read more ...

Menlo's Itching Drug Racks Up Two More Trial Failures, Program Ends

Menlo's Itching Drug Racks Up Two More Trial Failures, Program Ends

An itching drug that was a key part of the merger of Menlo Therapeutics and Foamix Pharmaceuticals has failed two late-stage studies, leading to a halt on further development... Read more ...

Premier Biomedical Realigns Business to Eliminate Convertible Debt, Cancel...

Premier Biomedical Realigns Business to Eliminate Convertible Debt, Cancel Reverse Split & Fund Covid-19 R&D

Jackson Center, PA, April 6, 2020 - Premier Biomedical, Inc. announced a multi-faceted agreement to eliminate the Convertible Notes as an obligation of Premier, cancel the... Read more ...

GSK, Vir Team Up in COVID-19 Pact Aiming to Reach the Clinic in Months

GSK, Vir Team Up in COVID-19 Pact Aiming to Reach the Clinic in Months

GlaxoSmithKline has agreed to invest $250 million in infectious disease specialist Vir Biotechnology to launch a COVID-19 R&D alliance that the companies say could advance two... Read more ...

Xconomy Releases Coronavirus Special Report on Containing the Pandemic...

Xconomy Releases Coronavirus Special Report on Containing the Pandemic Through Innovation & Investment

Based on the latest news and analysis, as well as conversations from industry experts during the Combatting Coronavirus live panel at BIO-Europe Spring®, Xconomy's free special... Read more ...