SPLICE-AWARE RNA-SEQ DATA SIMULATION

AbstractSummaryA plethora of tools exist for RNA-Seq data analysis with a focus on alternative splicing. However, appropriate data...

CCMED: CROSS-CONDITION MEDIATION ANALYSIS FOR IDENTIFYING REPLICABLE TRANS-ASSOCIATIONS MEDIATED BY CIS-GENE EXPRESSION

AbstractMotivationTrans-acting expression quantitative trait loci collectively explain a substantial proportion of expression variation,...

 
 
 

BLINKING STATISTICS AND MOLECULAR COUNTING IN DIRECT STOCHASTIC RECONSTRUCTION MICROSCOPY

AbstractMotivationMany recent advancements in single molecule localisation microscopy exploit the stochastic photo-switching of fluorophores...

A MODELLING FRAMEWORK FOR EMBEDDING-BASED PREDICTIONS FOR COMPOUND-VIRAL PROTEIN ACTIVITY

AbstractMotivationA global effort is underway to identify compounds for the treatment of COVID-19. Since de novo compound design is...

 
 
 

HETEROGGM: AN R PACKAGE FOR GAUSSIAN GRAPHICAL MODEL-BASED HETEROGENEITY ANALYSIS

AbstractSummaryHeterogeneity is a hallmark of many complex human diseases, and unsupervised heterogeneity analysis has been extensively...

BERT4BITTER: A BIDIRECTIONAL ENCODER REPRESENTATIONS FROM TRANSFORMERS -BASED MODEL FOR IMPROVING THE PREDICTION OF BITTER PEPTIDES

AbstractMotivationThe identification of bitter peptides through experimental approaches is an expensive and time-consuming endeavor....

 
 
 

PICS2: NEXT-GENERATION FINE MAPPING VIA PROBABILISTIC IDENTIFICATION OF CAUSAL SNPS

Abstract The Probabilistic Identification of Causal SNPs algorithm and web application was developed as a fine-mapping tool to determine...

D-PBWT: DYNAMIC POSITIONAL BURROWS-WHEELER TRANSFORM

AbstractMotivationDurbin's positional Burrows-Wheeler transform is a scalable data structure for haplotype matching. It has been successfully...

 
 
 

BLOODGEN3MODULE: BLOOD TRANSCRIPTIONAL MODULE REPERTOIRE ANALYSIS AND VISUALIZATION USING R

AbstractMotivationWe previously described the construction and characterization of generic and reusable blood transcriptional module...

LNCLOCATOR 2.0: A CELL-LINE-SPECIFIC SUBCELLULAR LOCALIZATION PREDICTOR FOR LONG NON-CODING RNAS WITH INTERPRETABLE DEEP LEARNING

AbstractMotivationLong non-coding RNAs are generally expressed in a tissue-specific way, and subcellular localizations of lncRNAs depend...

 
 
 

PRIVACY-PRESERVING AND ROBUST WATERMARKING ON SEQUENTIAL GENOME DATA USING BELIEF PROPAGATION AND LOCAL DIFFERENTIAL PRIVACY

AbstractMotivationGenome data is a subject of study for both biology and computer science since the start of the Human Genome Project...

ESCO: SINGLE CELL EXPRESSION SIMULATION INCORPORATING GENE CO-EXPRESSION

AbstractMotivationGene-gene co-expression networks are of biological interest for the useful information they provide for understanding...

 
 
 

E-MAGMA: AN EQTL-INFORMED METHOD TO IDENTIFY RISK GENES USING GENOME-WIDE ASSOCIATION STUDY SUMMARY STATISTICS

AbstractMotivationGenome-wide association studies have successfully identified multiple independent genetic loci that harbour variants...

AN ENHANCED LOSS FUNCTION SIMPLIFIES THE DEEP LEARNING MODEL FOR CHARACTERIZING THE 3D ORGANOID MODELS

AbstractMotivationOrganization of the organoid models, imaged in 3D with a confocal microscope, is an essential morphometric index...

 
 
 

ACTIVE LEARNING TO CLASSIFY MACROMOLECULAR STRUCTURES IN SITU FOR LESS SUPERVISION IN CRYO-ELECTRON TOMOGRAPHY

AbstractMotivationCryo-Electron Tomography is a 3D bioimaging tool that visualizes the structural and spatial organization of macromolecules...

VOROCNN: DEEP CONVOLUTIONAL NEURAL NETWORK BUILT ON 3D VORONOI TESSELLATION OF PROTEIN STRUCTURES

AbstractMotivationEffective use of evolutionary information has recently led to tremendous progress in computational prediction of...

 
 
 

A VARIABLE SELECTION APPROACH FOR HIGHLY CORRELATED PREDICTORS IN HIGH-DIMENSIONAL GENOMIC DATA

AbstractMotivationIn genomic studies, identifying biomarkers associated with a variable of interest is a major concern in biomedical...

INFERRING PERTURBATION PROFILES OF CANCER SAMPLES

AbstractMotivationCancer is one of the most prevalent diseases in theworld. Tumors arise due to important genes changing their activity,...

 
 
 

GRAPH CONTEXTUALIZED ATTENTION NETWORK FOR PREDICTING SYNTHETIC LETHALITY IN HUMAN CANCERS

AbstractMotivationSynthetic Lethality plays an increasingly critical role in the targeted anticancer therapeutics. In addition, identifying...

CUBLOCK: A CROSS-PLATFORM NORMALIZATION METHOD FOR GENE-EXPRESSION MICROARRAYS

AbstractMotivationCross-platform normalization of gene-expression microarray data remains an unresolved issue. Despite the existence...

 
 
 



World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Structural insights into homotrimeric assembly of cellulose synthase CesA7...

Summary Cellulose is one of the most abundant organic polymers in nature. It contains multiple β‐1,4‐glucan chains synthesized by cellulose synthases on the plasma membrane of... Read more ...

Wheat with greatly reduced accumulation of free asparagine in the grain...

Summary Free asparagine is the precursor for acrylamide, which forms during the baking, toasting and high‐temperature processing of foods made from wheat. In this study... Read more ...

Accurate and fast mitotic detection using an anchor-free method based on...

To effectively detect and investigate various cell-related diseases, it is essential to understand cell behaviour. The ability to detection mitotic cells is a fundamental step... Read more ...

Biomedical articles share annotations with their citation neighbors

Numerous efforts have been poured into annotating the wealth of knowledge contained in biomedical articles. Thanks to such efforts, it is now possible to quantitatively explore... Read more ...

Blinking Statistics and Molecular Counting in direct Stochastic...

AbstractMotivationMany recent advancements in single molecule localisation microscopy exploit the stochastic photo-switching of fluorophores to reveal complex cellular... Read more ...

CCmed: Cross-condition mediation analysis for identifying replicable...

AbstractMotivationTrans-acting expression quantitative trait loci collectively explain a substantial proportion of expression variation, yet are challenging to detect and... Read more ...

Splice-aware RNA-Seq data simulation

AbstractSummaryA plethora of tools exist for RNA-Seq data analysis with a focus on alternative splicing. However, appropriate data for their comparative evaluation is missing... Read more ...

Signs point to COVID-19 vaccines slowing viral transmission, not just disease

Researchers say recent findings bode well for vaccines helping slow the spread of the pandemic... Read more ...

Thermo Fisher completes $450M acquisition of San Diego COVID test maker Mesa...

Mesa developed a desktop, molecular COVID-19 test that delivers results in as little as 30 minutes... Read more ...

How Can PSC® Help You Succeed During COVID

How Can PSC® Help You Succeed During COVID

Written By: Akshaya Mohan, Regulatory Affairs Manager, PSC Biotech® The COVID pandemic of 2020-21 has impacted the Life Science companies in myriad ways. The greatest impact... Read more ...