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Microbial Cell Factories

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EFFICIENT BIOSYNTHESIS OF CINNAMYL ALCOHOL BY ENGINEERED ESCHERICHIA COLI OVEREXPRESSING CARBOXYLIC ACID REDUCTASE IN A BIPHASIC SYSTEM

Cinnamyl alcohol is not only a kind of flavoring agent and fragrance, but also a versatile chemical applied in the production of various...

A COMMON APPROACH FOR ABSOLUTE QUANTIFICATION OF SHORT CHAIN COA THIOESTERS IN PROKARYOTIC AND EUKARYOTIC MICROBES

Thioesters of coenzyme A participate in 5% of all enzymatic reactions. In microbial cell factories, they function as building blocks...

 
 
 

THE LOCAL TRANSCRIPTIONAL REGULATORS SACR1 AND SACR2 ACT AS REPRESSORS OF FRUCTOOLIGOSACCHARIDES METABOLISM IN LACTOBACILLUS PLANTARUM

In Lactobacillus plantarum, fructooligosaccharides metabolism is controlled by both global and local regulatory mechanisms. Although...

EFFICIENT 2,3-BUTANEDIOL PRODUCTION FROM WHEY POWDER USING METABOLICALLY ENGINEERED KLEBSIELLA OXYTOCA

Whey is a major pollutant generated by the dairy industry. To decrease environmental pollution caused by the industrial release of...

 
 
 

TAK-242 AMELIORATES DSS-INDUCED COLITIS BY REGULATING THE GUT MICROBIOTA AND THE JAK2/STAT3 SIGNALING PATHWAY

The goal of the present study was to investigate the effects of TAK-242 on the gut microbiota and the TLR4/JAK2/STAT3 signaling pathway...

ACTIVATION AND ENHANCEMENT OF CAERULOMYCIN A BIOSYNTHESIS IN MARINE-DERIVED ACTINOALLOTEICHUS SP. AHMU CJ021 BY COMBINATORIAL GENOME MINING STRATEGIES

Activation of silent biosynthetic gene clusters in marine-derived actinomycete strains is a feasible strategy to discover bioactive...

 
 
 

CYCLODEXTRINASE FROM THERMOCOCCUS SP EXPRESSED IN BACILLUS SUBTILIS AND ITS APPLICATION IN THE PREPARATION OF MALTOHEPTAOSE

Maltoheptaose as malto-oligosaccharides with specific degree of polymerization, has wide applications in food, medicine and cosmetics...

ENGINEERING MARINE FUNGI FOR CONVERSION OF D-GALACTURONIC ACID TO MUCIC ACID

Two marine fungi, a Trichoderma sp. and a Coniochaeta sp., which can grow on d-galacturonic acid and pectin, were selected as hosts...

 
 
 

THE LENGTH OF RIBOSOMAL BINDING SITE SPACER SEQUENCE CONTROLS THE PRODUCTION YIELD FOR INTRACELLULAR AND SECRETED PROTEINS BY BACILLUS SUBTILIS

Bacillus subtilis is widely used for the industrial production of recombinant proteins, mainly due to its high secretion capacity,...

CONSTRUCTING A NOVEL EXPRESSION SYSTEM BY SPECIFIC ACTIVATION OF AMYLASE EXPRESSION PATHWAY IN PENICILLIUM

Filamentous fungi have long been used as hosts for the production of proteins, enzymes and valuable products in various biotechnological...

 
 
 

ESTABLISHMENT OF A FUNCTIONAL SYSTEM FOR RECOMBINANT PRODUCTION OF SECRETED PROTEINS AT 50 °C IN THE THERMOPHILIC BACILLUS METHANOLICUS

The suitability of bacteria as microbial cell factories is dependent on several factors such as price of feedstock, product range,...

SEXUAL DIMORPHISM OF GUT MICROBIOTA AT DIFFERENT PUBERTAL STATUS

Accumulating evidence infer that gut microbiome-host relations are key mediators or modulators driving the observed sexual dimorphism...

 
 
 

DELETION OF PGI GENE IN E. COLI INCREASES TOLERANCE TO FURFURAL AND 5-HYDROXYMETHYL FURFURAL IN MEDIA CONTAINING GLUCOSE-XYLOSE MIXTURE

Furfural and 5-hydroxymethyl furfural are key furan inhibitors that are generated due to breakdown of lignocellulosic sugars at high...

METABOLIC ENGINEERING OF ESCHERICHIA COLI FOR OPTIMIZED BIOSYNTHESIS OF NICOTINAMIDE MONONUCLEOTIDE, A NONCANONICAL REDOX COFACTOR

Noncanonical redox cofactors are emerging as important tools in cell-free biosynthesis to increase the economic viability, to enable...

 
 
 

IMPROVING THE FERMENTABLE SUGAR YIELDS OF WHEAT STRAW BY HIGH-TEMPERATURE PRE-HYDROLYSIS WITH THERMOPHILIC ENZYMES OF MALBRANCHEA CINNAMOMEA

Enzymatic hydrolysis is a key step in the conversion of lignocellulosic polysaccharides to fermentable sugars for the production of...

A NOVEL KNOCK OUT STRATEGY TO ENHANCE RECOMBINANT PROTEIN EXPRESSION IN ESCHERICHIA COLI

The expression of recombinant proteins triggers a stress response which downregulates key metabolic pathway genes leading to a decline...

 
 
 

PRODUCTION AND CHARACTERIZATION OF SURFACTIN-LIKE BIOSURFACTANT PRODUCED BY NOVEL STRAIN BACILLUS NEALSONII S2MT AND IT'S POTENTIAL FOR OIL CONTAMINATED SOIL REMEDIATION

Biosurfactants, being highly biodegradable, ecofriendly and multifunctional compounds have wide applications in various industrial...

ENGINEERING TRANSCRIPTION FACTOR-BASED BIOSENSORS FOR REPRESSIVE REGULATION THROUGH TRANSCRIPTIONAL DEACTIVATION DESIGN IN SACCHAROMYCES CEREVISIAE

With the development of engineering the microbial cell factories, biosensors have been used widely for regulation of cellular metabolism...

 
 
 

INCREASED SALT TOLERANCE IN ZYMOMONAS MOBILIS STRAIN GENERATED BY ADAPTATIVE EVOLUTION

Ethanologenic alphaproteobacterium Zymomonas mobilis has been acknowledged as a promising biofuel producer. There have been numerous...

GENOME SCALE METABOLIC MODEL OF THE VERSATILE METHANOTROPH METHYLOCELLA SILVESTRIS

Methylocella silvestris is a facultative aerobic methanotrophic bacterium which uses not only methane, but also other alkanes such...

 
 
 



World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

How COVID-19 Arose and Amplified Along the Meat Supply Chain

How COVID-19 Arose and Amplified Along the Meat Supply Chain

Early in this unforgettable year, a wet market in Wuhan, China, emerged as a possible step along the way, if not the place of origin, of the outbreak that would seed the... Read more ...

Global Methane Emissions Soaring, But How Much Was Due to Wetlands?

Global Methane Emissions Soaring, But How Much Was Due to Wetlands?

Infographic published with permission from the authors of “Increasing anthropogenic methane emissions arise equally from agricultural and fossil fuel sources.” (Credit: Jackson... Read more ...

Computer System Assurance: A Paradigm Shift Away from Compliance to Quality

Computer System Assurance: A Paradigm Shift Away from Compliance to Quality

Our Professional Services Written by: Gary E. Ritchie, MS, Senior Validation Engineer Consultant, PSC Biotech Corporation The FDA will release the draft guidance on Computer... Read more ...

With FDA Nod, NS Pharma Duchenne Drug Becomes Sarepta Competitor

With FDA Nod, NS Pharma Duchenne Drug Becomes Sarepta Competitor

Duchenne muscular dystrophy patients whose disease is characterized by a particular genetic mutation now have a new treatment option following the FDA's Wednesday approval of a... Read more ...

Perceptive Advisors' LianBio Inks Deals With BridgeBio, MyoKardia

Perceptive Advisors' LianBio Inks Deals With BridgeBio, MyoKardia

Two California biotechs have teamed up with LianBio, a new company launched earlier this week by hedge fund Perceptive Advisors, as part of deals that expand their reach into... Read more ...

F2G Lands $60M for a New Tack on Taking Out Rare Fungal Infections

F2G Lands $60M for a New Tack on Taking Out Rare Fungal Infections

Fungal infections might not immediately come to mind as rare diseases, but growing resistance to older drugs means that patients who develop these infections have limited... Read more ...

Calliditas gets controlling stake, option to buy out Genkyotex and its...

Calliditas gets controlling stake, option to buy out Genkyotex and its failed PBC drug badams Fri, 08/14/2020 - 05:07 Read more ...

17β-Estradiol affects the innate immune response in common carp

Abstract Inflammation is the evolutionary conserved immune response to harmful stimuli such as pathogens or damaged cells. This multistep process acts by removing injurious... Read more ...

Chutes & Ladders-WuXi taps veteran operations head Dong to lead new vaccines...

Chutes & Ladders-WuXi taps veteran operations head Dong to lead new vaccines unit kblankenship Fri, 08/14/2020 - 08:23 Read more ...

Team discovers a new role for a well-known molecule as a plant hormone

Researchers at the University of Maryland have discovered an entirely new role for a well-known plant molecule called ACC, providing the first clear example of ACC acting on... Read more ...