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Journal of Biosciences

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Α-HELICAL PROTEIN ABSORPTION AT POST-TRAUMATIC EPILEPTIC FOCI MONITORED BY FOURIER TRANSFORM INFRARED MAPPING

Abstract Tissue analysis by Fourier transform infrared imaging can determine the biodistribution of molecules, without pre-analytical...

CATALYTIC AND STRUCTURAL EFFECTS OF FLEXIBLE LOOP DELETION IN ORGANOPHOSPHORUS HYDROLASE ENZYME: A THERMOSTABILITY IMPROVEMENT MECHANISM

Abstract Thermostability improvement of enzymes used industrially or commercially would develop their capacity and commercial potential...

 
 
 

PSCRIDB: A DATABASE OF REGULATORY INTERACTIONS AND NETWORKS OF PLURIPOTENT STEM CELL LINES

Abstract Pluripotency in stem cells is regulated by a complex network between the transcription factors, signaling molecules, mRNAs,...

LNCRNA XIST KNOCKDOWN AMELIORATES OXIDATIVE LOW-DENSITY LIPOPROTEIN-INDUCED ENDOTHELIAL CELLS INJURY BY TARGETING MIR-204-5P/TLR4

Abstract Oxidative low-density lipoprotein -induced endothelial cell injury is a key contributor to atherosclerosis development. However,...

 
 
 

THE LONG NON-CODING RNA MIAT/MIR-139-5P/MMP2 AXIS REGULATES CELL MIGRATION AND INVASION IN NON-SMALL-CELL LUNG CANCER

Abstract Non-small-cell lung cancer is a complex disease which is influenced by multiple factors. Recent studies demonstrated that...

T CELL COSTIMULATION, CHECKPOINT INHIBITORS AND ANTI-TUMOR THERAPY

Abstract The hallmarks of the adaptive immune response are specificity and memory. The cellular response is mediated by T cells which...

 
 
 

EFFECTS OF NICORANDIL ON NEUROBEHAVIORAL FUNCTION, BBB INTEGRITY, EDEMA AND STEREOLOGICAL PARAMETERS OF THE BRAIN IN THE SUB-ACUTE PHASE OF STROKE IN A RAT MODEL

Abstract Blood-brain barrier disruption, inflammation, and cell death are the pathogenic mechanisms of cerebral ischemia/reperfusion...

MIR-140-3P INHIBITS PROGRESSION OF NON-SMALL CELL LUNG CANCER BY TARGETING JANUS KINASE 1

Abstract microRNAs have gained more attention due to the biological functions in many cancers, including non-small cell lung cancer....

 
 
 

EPHEDRANNIN B EXERTS ANTI-VIRAL AND ANTI-INFLAMMATORY PROPERTIES IN BEAS-2B CELLS INFECTED WITH RESPIRATORY SYNCYTIAL VIRUS

Abstract Ephedrannin B has been shown to exert anti-inflammatory effects. However, the effect of EPB on respiratory syncytial virus...

MIR-4417 SUPPRESSES KELOID FIBROSIS GROWTH BY INHIBITING CYCLIND1

Abstract Mounting evidence has reported that microRNAs play irreplaceable roles in the development of keloid fibrosis. miR-4417 has...

 
 
 

LNCRNA XIST INTERACTS WITH MIR-454 TO INHIBIT CELLS PROLIFERATION, EPITHELIAL MESENCHYMAL TRANSITION AND INDUCES APOPTOSIS IN TRIPLE-NEGATIVE BREAST CANCER

Abstract Triple-negative breast cancer is a one of the subtypes of breast cancer which accounts for approximately 10-20% of all breast...

QUINACRINE CAUSES APOPTOSIS IN HUMAN CANCER CELL LINES THROUGH CASPASE-MEDIATED PATHWAY AND REGULATION OF SMALL-GTPASE

Abstract Quinacrine , an FDA-approved anti-malarial drug, has shown to have anticancer activities. Due to its ‘shotgun' nature, QC...

 
 
 

QUANTITATIVE DETECTION OF NEUROTRANSMITTER USING APTAMER: FROM DIAGNOSIS TO THERAPEUTICS

Abstract Neurotransmitters, the small molecule chemical messenger responsible for nervous system regulation and can control joy, fear,...

TRANSCRIPTOME-WIDE IDENTIFICATION AND PROFILING OF MIRNAS IN A STRESS-TOLERANT CONIFER SABINA CHINENSIS

Abstract miRNAs are important regulatory components involving in many biological processes, including plant development, vegetative...

 
 
 

SILENCING OF HOXB9 SUPPRESSES CELLULAR PROLIFERATION, ANGIOGENESIS, MIGRATION AND INVASION OF PROSTATE CANCER CELLS

Abstract The Homeobox B9 is a homeodomain-containing transcription factor that participates in the progression of various malignancies....

RESVERATROL PROTECTS H9C2 CELLS AGAINST HYPOXIA-INDUCED APOPTOSIS THROUGH MIR-30D-5P/SIRT1/NF-ΚB AXIS

Abstract Previous studies have demonstrated the cardioprotective role of resveratrol. However, the underlying molecular mechanisms...

 
 
 

X-MODULE: A NOVEL FUSION MEASURE TO ASSOCIATE CO-EXPRESSED GENE MODULES FROM CONDITION-SPECIFIC EXPRESSION PROFILES

Abstract A gene co-expression network is of biological interest, since co-expressed genes share common functions and biological processes...

INTERACTOME OF VERTEBRATE GAF/THPOK REVEALS ITS DIVERSE FUNCTIONS IN GENE REGULATION AND DNA REPAIR

Abstract GAGA associated factor is a sequence-specific DNA binding transcription factor that is evolutionarily conserved from flies...

 
 
 

YEAST GLUTAREDOXIN, GRX4, FUNCTIONS AS A GLUTATHIONE S-TRANSFERASE REQUIRED FOR RED ADE PIGMENT FORMATION IN SACCHAROMYCES CEREVISIAE

Abstract The adenine biosynthetic mutants ade1 and ade2 of Saccharomyces cerevisiae accumulate a characteristic red pigment in their...

Β-ACTIN FACILITATES ETOPOSIDE-INDUCED P53 NUCLEAR IMPORT

Abstract As a tumor suppressor, p53 preserves genomic integrity in eukaryotes. However, limited evidence is available for the p53 shuttling...

 
 
 



World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Convalescent Plasma: A Therapy for COVID-19?

Convalescent Plasma: A Therapy for COVID-19?

To develop a treatment for patients with COVID-19, researchers around the world are steadfastly exploring numerous angles, including testing existing antiviral drugs and new... Read more ...

Inovio Begins Experimental COVID-19 Vaccine Tests in Healthy Volunteers

Inovio Begins Experimental COVID-19 Vaccine Tests in Healthy Volunteers

Inovio Pharmaceuticals, one of the biotechs developing a vaccine to prevent COVID-19, has received the FDA's OK to start testing its candidate in healthy volunteers. The... Read more ...

Sage Restructuring Halves Staff, Turns Focus to Failed Depression Drug

Sage Restructuring Halves Staff, Turns Focus to Failed Depression Drug

Sage Therapeutics is cutting workers who sell its only commercialized drug in a corporate reorganization that it says allows it to focus on clinical-stage compounds, including... Read more ...

Creating Consistent Value in Biotech Without Diluting Stakeholders

Creating Consistent Value in Biotech Without Diluting Stakeholders

One of the greatest challenges for pre-commercial biotech companies is consistently generating capital necessary for operating costs and for R&D of new products that provide... Read more ...

Interactive, Online Xcelerating Life Sciences Boston Event Set for May 13

Interactive, Online Xcelerating Life Sciences Boston Event Set for May 13

In the Boston biotech hub, much progress has been made advancing digital health, but significant scientific, technological, financial, and regulatory challenges remain. Join us... Read more ...

Millendo May Restructure After Prader-Willi Drug Fails Pivotal Test

Millendo May Restructure After Prader-Willi Drug Fails Pivotal Test

Millendo Therapeutics is considering a corporate reorganization after its lead drug, an investigational treatment for a rare genetic condition characterized by unrelenting... Read more ...

Menlo's Itching Drug Racks Up Two More Trial Failures, Program Ends

Menlo's Itching Drug Racks Up Two More Trial Failures, Program Ends

An itching drug that was a key part of the merger of Menlo Therapeutics and Foamix Pharmaceuticals has failed two late-stage studies, leading to a halt on further development... Read more ...

Premier Biomedical Realigns Business to Eliminate Convertible Debt, Cancel...

Premier Biomedical Realigns Business to Eliminate Convertible Debt, Cancel Reverse Split & Fund Covid-19 R&D

Jackson Center, PA, April 6, 2020 - Premier Biomedical, Inc. announced a multi-faceted agreement to eliminate the Convertible Notes as an obligation of Premier, cancel the... Read more ...

GSK, Vir Team Up in COVID-19 Pact Aiming to Reach the Clinic in Months

GSK, Vir Team Up in COVID-19 Pact Aiming to Reach the Clinic in Months

GlaxoSmithKline has agreed to invest $250 million in infectious disease specialist Vir Biotechnology to launch a COVID-19 R&D alliance that the companies say could advance two... Read more ...

Xconomy Releases Coronavirus Special Report on Containing the Pandemic...

Xconomy Releases Coronavirus Special Report on Containing the Pandemic Through Innovation & Investment

Based on the latest news and analysis, as well as conversations from industry experts during the Combatting Coronavirus live panel at BIO-Europe Spring®, Xconomy's free special... Read more ...