HAPLOTYPE THREADING: ACCURATE POLYPLOID PHASING FROM LONG READS

Resolving genomes at haplotype level is crucial for understanding the evolutionary history of polyploid species and for designing advanced...

ULTRASENSITIVE DELETION DETECTION LINKS MITOCHONDRIAL DNA REPLICATION, DISEASE, AND AGING

Acquired human mitochondrial genome deletions are symptoms and drivers of focal mitochondrial respiratory deficiency, a pathological...

 
 
 

BIFROST: HIGHLY PARALLEL CONSTRUCTION AND INDEXING OF COLORED AND COMPACTED DE BRUIJN GRAPHS

Memory consumption of de Bruijn graphs is often prohibitive. Most de Bruijn graph-based assemblers reduce the complexity by compacting...

REMOVING REFERENCE BIAS AND IMPROVING INDEL CALLING IN ANCIENT DNA DATA ANALYSIS BY MAPPING TO A SEQUENCE VARIATION GRAPH

During the last decade, the analysis of ancient DNA sequence has become a powerful tool for the study of past human populations. However,...

 
 
 

CHROMATIN REGULATES EXPRESSION OF SMALL RNAS TO HELP MAINTAIN TRANSPOSON METHYLOME HOMEOSTASIS IN ARABIDOPSIS

Eukaryotic genomes are partitioned into euchromatic and heterochromatic domains to regulate gene expression and other fundamental cellular...

AUTHENTICT: A MODEL OF ANCIENT DNA DAMAGE TO ESTIMATE THE PROPORTION OF PRESENT-DAY DNA CONTAMINATION

Contamination from present-day DNA is a fundamental issue when studying ancient DNA from historical or archaeological material, and...

 
 
 

CANCER-SPECIFIC CTCF BINDING FACILITATES ONCOGENIC TRANSCRIPTIONAL DYSREGULATION

The three-dimensional genome organization is critical for gene regulation and can malfunction in diseases like cancer. As a key regulator...

MERQURY: REFERENCE-FREE QUALITY, COMPLETENESS, AND PHASING ASSESSMENT FOR GENOME ASSEMBLIES

Recent long-read assemblies often exceed the quality and completeness of available reference genomes, making validation challenging....

 
 
 

PTWAS: INVESTIGATING TISSUE-RELEVANT CAUSAL MOLECULAR MECHANISMS OF COMPLEX TRAITS USING PROBABILISTIC TWAS ANALYSIS

We propose a new computational framework, probabilistic transcriptome-wide association study , to investigate causal relationships...

IMPACT OF ADMIXTURE AND ANCESTRY ON EQTL ANALYSIS AND GWAS COLOCALIZATION IN GTEX

Population structure among study subjects may confound genetic association studies, and lack of proper correction can lead to spurious...

 
 
 

A VAST RESOURCE OF ALLELIC EXPRESSION DATA SPANNING HUMAN TISSUES

Allele expression analysis robustly measures cis-regulatory effects. Here, we present and demonstrate the utility of a vast AE resource...

SN-SPMF: MATRIX FACTORIZATION INFORMS TISSUE-SPECIFIC GENETIC REGULATION OF GENE EXPRESSION

Genetic regulation of gene expression, revealed by expression quantitative trait loci , exhibits complex patterns of tissue-specific...

 
 
 

PRIMO: INTEGRATION OF MULTIPLE GWAS AND OMICS QTL SUMMARY STATISTICS FOR ELUCIDATION OF MOLECULAR MECHANISMS OF TRAIT-ASSOCIATED SNPS AND DETECTION OF PLEIOTROPY IN COMPLEX TRAITS

To provide a comprehensive mechanistic interpretation of how known trait-associated SNPs affect complex traits, we propose a method,...

METALIGN: EFFICIENT ALIGNMENT-BASED METAGENOMIC PROFILING VIA CONTAINMENT MIN HASH

Metagenomic profiling, predicting the presence and relative abundances of microbes in a sample, is a critical first step in microbiome...

 
 
 

STARR-SEQ IDENTIFIES ACTIVE, CHROMATIN-MASKED, AND DORMANT ENHANCERS IN PLURIPOTENT MOUSE EMBRYONIC STEM CELLS

Enhancers are distal regulators of gene expression that shape cell identity and control cell fate transitions. In mouse embryonic stem...

ESTIMATING THE QUALITY OF EUKARYOTIC GENOMES RECOVERED FROM METAGENOMIC ANALYSIS WITH EUKCC

Microbial eukaryotes constitute a significant fraction of biodiversity and have recently gained more attention, but the recovery of...

 
 
 

NATURAL DISPLAY OF NUCLEAR-ENCODED RNA ON THE CELL SURFACE AND ITS IMPACT ON CELL INTERACTION

Compared to proteins, glycans, and lipids, much less is known about RNAs on the cell surface. We develop a series of technologies to...

GETORGANELLE: A FAST AND VERSATILE TOOLKIT FOR ACCURATE DE NOVO ASSEMBLY OF ORGANELLE GENOMES

GetOrganelle is a state-of-the-art toolkit to accurately assemble organelle genomes from whole genome sequencing data. It recruits...

 
 
 

THE WILD GRAPE GENOME SEQUENCE PROVIDES INSIGHTS INTO THE TRANSITION FROM DIOECY TO HERMAPHRODITISM DURING GRAPE DOMESTICATION

A key step in domestication of the grapevine was the transition from separate sexes in wild Vitis vinifera ssp. sylvestris to hermaphroditism...

THE TUG1 LNCRNA LOCUS IS ESSENTIAL FOR MALE FERTILITY

Several long noncoding RNAs have been shown to function as components of molecular machines that play fundamental roles in biology....

 
 
 



World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Tau-Targeting Alzheimer's Drug from AC Immune, Roche Fails in Phase 2

Tau-Targeting Alzheimer's Drug from AC Immune, Roche Fails in Phase 2

An Alzheimer's disease drug from partners AC Immune and Roche has failed a mid-stage clinical trial, adding another compound to the list of experimental therapies that have... Read more ...

Athira CEO Kawas: Alzheimer's Drug Aims for “Recovery of Brain Function”

Athira CEO Kawas: Alzheimer's Drug Aims for “Recovery of Brain Function”

The key to Athira Pharma's approach to Alzheimer's disease is already inside each of us: a repair mechanism that can regenerate damaged neurons. What's needed to begin the... Read more ...

Gene Therapy Firms Seek Clarity on FDA Exclusivity, Orphan Designations

Gene Therapy Firms Seek Clarity on FDA Exclusivity, Orphan Designations

Gene therapy product developers are seeking more clarity from the US Food and Drug Administration on when viral vectors from the same class will be considered sufficiently... Read more ...

Checkmate, Chromosome 8: The First End-to-End Sequence of a Human Autosome

Checkmate, Chromosome 8: The First End-to-End Sequence of a Human Autosome

Even in the field of genomics where new breakthroughs occur every few months, completion of the first-ever fully sequenced human autosome is a momentous achievement. Highly... Read more ...

Illumina to Acquire Cancer Diagnostics Developer Grail in $8B Deal

Illumina to Acquire Cancer Diagnostics Developer Grail in $8B Deal

Grail is set to be acquired for $8 billion by Illumina, the gene sequencing giant that formed the cancer diagnostics developer and spun it out as a separate company four years... Read more ...

Xconomy Awards On-Demand ‘Meet the Finalists' Webcast Series Continues This Week

Xconomy Awards On-Demand ‘Meet the Finalists' Webcast Series Continues This Week

The 2020 National Xconomy Awards complimentary two-week, 11-part, on-demand Meet the Finalists daily webcast series continues this Tuesday and Wednesday at 11 a.m. ET... Read more ...

Engineering Graduate Students Honored as Siebel Scholars

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Unraveling the genome in 3-D space

Proper folding of extremely long chromosomal DNA molecules is crucial for the correct functioning of the cell. Scientists from the Gerlich lab at IMBA-Institute of Molecular... Read more ...

Patented 'molecular heaters' to increase crop yield

Researchers at the University of Amsterdam have developed a novel class of molecules capable of raising the temperature of plants. Application of such molecular heaters allows... Read more ...

A class of low‐cost alternatives to kifunensine for increasing high mannose...

Abstract N‐linked glycosylation of therapeutic monoclonal antibodies is an important product quality attribute for drug safety and efficacy. An increase in the percent of high... Read more ...