SCREENING FOR GENES THAT ACCELERATE THE EPIGENETIC AGING CLOCK IN HUMANS REVEALS A ROLE FOR THE H3K36 METHYLTRANSFERASE NSD1

Epigenetic clocks are mathematical models that predict the biological age of an individual using DNA methylation data and have emerged...

SCALIGN: A TOOL FOR ALIGNMENT, INTEGRATION, AND RARE CELL IDENTIFICATION FROM SCRNA-SEQ DATA

ScRNA-seq dataset integration occurs in different contexts, such as the identification of cell type-specific differences in gene expression...

 
 
 

ALLELEANALYZER: A TOOL FOR PERSONALIZED AND ALLELE-SPECIFIC SGRNA DESIGN

The CRISPR/Cas system is a highly specific genome editing tool capable of distinguishing alleles differing by even a single base pair....

AN ENHANCED GENETIC MODEL OF COLORECTAL CANCER PROGRESSION HISTORY

The classical genetic model of colorectal cancer presents APC mutations as the earliest genomic alterations, followed by KRAS and TP53...

 
 
 

BENCHMARKING SOFTWARE TOOLS FOR DETECTING AND QUANTIFYING SELECTION IN EVOLVE AND RESEQUENCING STUDIES

The combination of experimental evolution with whole-genome resequencing of pooled individuals, also called evolve and resequence is...

ANALYSIS OF VIBRIO CHOLERAE GENOMES IDENTIFIES NEW TYPE VI SECRETION SYSTEM GENE CLUSTERS

Like many bacteria, Vibrio cholerae deploys a harpoon-like type VI secretion system to compete against other microbes in environmental...

 
 
 

THE BIO.TOOLS REGISTRY OF SOFTWARE TOOLS AND DATA RESOURCES FOR THE LIFE SCIENCES

Bioinformaticians and biologists rely increasingly upon workflows for the flexible utilization of the many life science tools that...

BERMUDA: A NOVEL DEEP TRANSFER LEARNING METHOD FOR SINGLE-CELL RNA SEQUENCING BATCH CORRECTION REVEALS HIDDEN HIGH-RESOLUTION CELLULAR SUBTYPES

To fully utilize the power of single-cell RNA sequencing technologies for identifying cell lineages and bona fide transcriptional signals,...

 
 
 

IS IT TIME TO CHANGE THE REFERENCE GENOME?

The use of the human reference genome has shaped methods and data across modern genomics. This has offered many benefits while creating...

CORRECTION TO: IDENTIFICATION OF NOVEL Y CHROMOSOME ENCODED TRANSCRIPTS BY TESTIS TRANSCRIPTOME ANALYSIS OF MICE WITH DELETIONS OF THE Y CHROMOSOME LONG ARM

Following publication of the original article , the following error was reported: The actin control panel in Fig. 3 of this paper is...

 
 
 

CORRECTION TO: ANCIENT POLYMORPHISMS CONTRIBUTE TO GENOME-WIDE VARIATION BY LONG-TERM BALANCING SELECTION AND DIVERGENT SORTING IN BOECHERA STRICTA

Following publication of the original article , the authors reported that the Availability of data and materials section required updating....

QUANTITATIVE PRINCIPLES OF CIS-TRANSLATIONAL CONTROL BY GENERAL MRNA SEQUENCE FEATURES IN EUKARYOTES

General translational cis-elements are present in the mRNAs of all genes and affect the recruitment, assembly, and progress of preinitiation...

 
 
 

LINKER HISTONES ARE FINE-SCALE CHROMATIN ARCHITECTS MODULATING DEVELOPMENTAL DECISIONS IN ARABIDOPSIS

Chromatin provides a tunable platform for gene expression control. Besides the well-studied core nucleosome, H1 linker histones are...

A SYSTEMATIC ASSESSMENT OF CURRENT GENOME-SCALE METABOLIC RECONSTRUCTION TOOLS

Several genome-scale metabolic reconstruction software platforms have been developed and are being continuously updated. These tools...

 
 
 

MICROPRO: USING METAGENOMIC UNMAPPED READS TO PROVIDE INSIGHTS INTO HUMAN MICROBIOTA AND DISEASE ASSOCIATIONS

We develop a metagenomic data analysis pipeline, MicroPro, that takes into account all reads from known and unknown microbial organisms...

BART-SEQ: COST-EFFECTIVE MASSIVELY PARALLELIZED TARGETED SEQUENCING FOR GENOMICS, TRANSCRIPTOMICS, AND SINGLE-CELL ANALYSIS

We describe a highly sensitive, quantitative, and inexpensive technique for targeted sequencing of transcript cohorts or genomic regions...

 
 
 

RNA METHYLOMES REVEAL THE M6A-MEDIATED REGULATION OF DNA DEMETHYLASE GENE SLDML2 IN TOMATO FRUIT RIPENING

Methylation of nucleotides, notably in the forms of 5-methylcytosine in DNA and N6-methyladenosine in mRNA, carries important information...

A STATISTICAL AND BIOLOGICAL RESPONSE TO AN INFORMATICS APPRAISAL OF HEALTHY AGING GENE SIGNATURES

Jacob and Speed did not identify even a single example of a ‘150-gene-set' that was statistically significant at classifying Alzheimer's...

 
 
 

ASSIGNMENT OF VIRUS AND ANTIMICROBIAL RESISTANCE GENES TO MICROBIAL HOSTS IN A COMPLEX MICROBIAL COMMUNITY BY COMBINED LONG-READ ASSEMBLY AND PROXIMITY LIGATION

We describe a method that adds long-read sequencing to a mix of technologies used to assemble a highly complex cattle rumen microbial...

ALTERNATIVE SPLICING IS REQUIRED FOR STAGE DIFFERENTIATION IN MALARIA PARASITES

In multicellular organisms, alternative splicing is central to tissue differentiation and identity. Unicellular protists lack multicellular...

 
 
 



World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Robots and Africa: Tech transfer accelerates data collection

Robots and Africa: Tech transfer accelerates data collection

Ke Gao and Sam McInturf reveal Sun Bear to presidents and administrators of UWC and MU. By Mariah Cox | Bond LSC Fourteen days. That's how long it took Sam McInturf and Ke Gao... Read more ...

Pfizer Spinout SpringWorks, Migraine Drug Firm Satsuma Prep IPOs

Pfizer Spinout SpringWorks, Migraine Drug Firm Satsuma Prep IPOs

The dog days of summer are here and IPO activity has slowed, but that hasn't stopped some biotech companies from securing a place in the line leading to Wall Street. Late... Read more ...

AbbVie's Successor to Humira Wins FDA OK for Rheumatoid Arthritis

AbbVie's Successor to Humira Wins FDA OK for Rheumatoid Arthritis

An anti-inflammatory drug that AbbVie has been developing as a successor to adalimumab , the world's top-selling drug, won the regulatory OK Friday as a treatment for... Read more ...

USC and UC San Diego try to move on after painful fight over Alzheimer's...

Both schools say they're found a way to prosper while studying the inscrutable disease... Read more ...

Senior R&D Scientist - Single cell application - Universal Sequencing...

Design and execute experiments, and analyze data independently. Establish product quality control assays for in-process & final product test and deliver well...From Indeed... Read more ...

VIST - a Variant-Information Search Tool for precision oncology

Diagnosis and treatment decisions in cancer increasingly depend on a detailed analysis of the mutational status of a patient's genome. This analysis relies on previously... Read more ...

RF Purify: a novel tool for comprehensive analysis of tumor-purity in...

With the advent of array-based techniques to measure methylation levels in primary tumor samples, systematic investigations of methylomes have widely been performed on a large... Read more ...

Multitask learning for biomedical named entity recognition with...

Biomedical named entity recognition is a fundamental and essential task for biomedical literature mining, which affects the performance of downstream tasks. Most BioNER models... Read more ...

Characterization and mechanism of the effects of Mg-Fe layered double...

Layered double hydroxides have received widespread attention for their potential applications in catalysis, polymer nanocomposites, pharmaceuticals, and sensors. Here, the... Read more ...

Semiparametric estimation in regression with missing covariates using...

Abstract We investigate semiparametric estimation of regression coefficients through generalized estimating equations with single-index models when some covariates are missing... Read more ...