GENES ADAPT TO OUTSMART GENE-TARGETING STRATEGIES IN MUTANT MOUSE STRAINS BY SKIPPING EXONS TO REINITIATE TRANSCRIPTION AND TRANSLATION

Gene disruption in mouse embryonic stem cells or zygotes is a conventional genetics approach to identify gene function in vivo. However,...

GENOME-WIDE STUDIES REVEAL THE ESSENTIAL AND OPPOSITE ROLES OF ARID1A IN CONTROLLING HUMAN CARDIOGENESIS AND NEUROGENESIS FROM PLURIPOTENT STEM CELLS

Early human heart and brain development simultaneously occur during embryogenesis. Notably, in human newborns, congenital heart defects...

 
 
 

SIERRA: DISCOVERY OF DIFFERENTIAL TRANSCRIPT USAGE FROM POLYA-CAPTURED SINGLE-CELL RNA-SEQ DATA

High-throughput single-cell RNA-seq is a powerful tool for studying gene expression in single cells. Most current scRNA-seq bioinformatics...

DECODING THE EVOLUTIONARY RESPONSE TO PROSTATE CANCER THERAPY BY PLASMA GENOME SEQUENCING

Investigating genome evolution in response to therapy is difficult in human tissue samples. To address this challenge, we develop an...

 
 
 

MAPPING REGULATORY VARIANTS CONTROLLING GENE EXPRESSION IN DROUGHT RESPONSE AND TOLERANCE IN MAIZE

Gene expression is a key determinant of cellular response. Natural variation in gene expression bridges genetic variation to phenotypic...

EXPLORING NEIGHBORHOODS IN LARGE METAGENOME ASSEMBLY GRAPHS USING SPACEGRAPHCATS REVEALS HIDDEN SEQUENCE DIVERSITY

Genomes computationally inferred from large metagenomic data sets are often incomplete and may be missing functionally important content...

 
 
 

THE REGULATORY LANDSCAPE OF EARLY MAIZE INFLORESCENCE DEVELOPMENT

The functional genome of agronomically important plant species remains largely unexplored, yet presents a virtually untapped resource...

DYSREGULATION OF CANCER GENES BY RECURRENT INTERGENIC FUSIONS

Gene fusions have been studied extensively, as frequent drivers of tumorigenesis as well as potential therapeutic targets. In many...

 
 
 

QUANTILE NORMALIZATION OF SINGLE-CELL RNA-SEQ READ COUNTS WITHOUT UNIQUE MOLECULAR IDENTIFIERS

Single-cell RNA-seq profiles gene expression of individual cells. Unique molecular identifiers remove duplicates in read counts resulting...

SINGLE-CELL ATAC-SEQ SIGNAL EXTRACTION AND ENHANCEMENT WITH SCATE

Single-cell sequencing assay for transposase-accessible chromatin is the state-of-the-art technology for analyzing genome-wide regulatory...

 
 
 

GENOME-WIDE ANALYSES OF CHROMATIN INTERACTIONS AFTER THE LOSS OF POL I, POL II, AND POL III

The relationship between transcription and the 3D chromatin structure is debated. Multiple studies have shown that transcription affects...

GENOMIC ANALYSIS OF THE DOMESTICATION AND POST-SPANISH CONQUEST EVOLUTION OF THE LLAMA AND ALPACA

Despite their regional economic importance and being increasingly reared globally, the origins and evolution of the llama and alpaca...

 
 
 

IDENTIFICATION OF CELL TYPE-SPECIFIC METHYLATION SIGNALS IN BULK WHOLE GENOME BISULFITE SEQUENCING DATA

The traditional approach to studying the epigenetic mechanism CpG methylation in tissue samples is to identify regions of concordant...

ANALYSIS OF ENDOTHELIAL-TO-HAEMATOPOIETIC TRANSITION AT THE SINGLE CELL LEVEL IDENTIFIES CELL CYCLE REGULATION AS A DRIVER OF DIFFERENTIATION

Haematopoietic stem cells first arise during development in the aorta-gonad-mesonephros region of the embryo from a population of haemogenic...

 
 
 

ALLELE-SPECIFIC DNA METHYLATION IS INCREASED IN CANCERS AND ITS DENSE MAPPING IN NORMAL PLUS NEOPLASTIC CELLS INCREASES THE YIELD OF DISEASE-ASSOCIATED REGULATORY SNPS

Mapping of allele-specific DNA methylation can be a post-GWAS strategy for localizing regulatory sequence polymorphisms. The advantages...

COMPUTATIONAL INFERENCE OF CANCER-SPECIFIC VULNERABILITIES IN CLINICAL SAMPLES

Systematic in vitro loss-of-function screens provide valuable resources that can facilitate the discovery of drugs targeting cancer...

 
 
 

SUSTAINABLE AGRICULTURE IN THE ERA OF OMICS: KNOWLEDGE-DRIVEN CROP BREEDING

SINGLE-CELL TRANSCRIPTOME AND ANTIGEN-IMMUNOGLOBIN ANALYSIS REVEALS THE DIVERSITY OF B CELLS IN NON-SMALL CELL LUNG CANCER

Malignant transformation and progression of cancer are driven by the co-evolution of cancer cells and their dysregulated tumor microenvironment....

 
 
 

APPROACHES FOR INTEGRATING HETEROGENEOUS RNA-SEQ DATA REVEAL CROSS-TALK BETWEEN MICROBES AND GENES IN ASTHMATIC PATIENTS

Sputum induction is a non-invasive method to evaluate the airway environment, particularly for asthma. RNA sequencing of sputum samples...

ENHANCED INTEGRATED GRADIENTS: IMPROVING INTERPRETABILITY OF DEEP LEARNING MODELS USING SPLICING CODES AS A CASE STUDY

Despite the success and fast adaptation of deep learning models in biomedical domains, their lack of interpretability remains an issue....

 
 
 



World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Foghorn Therapeutics Inks Chromatin-Targeting Cancer Deal with Merck

Foghorn Therapeutics Inks Chromatin-Targeting Cancer Deal with Merck

Foghorn Therapeutics could receive up to $425 million in the development deal with Merck, its first partnership with a major biopharma. One way that a cell regulates which... Read more ...

Sanofi Pays Kymera $150M to Kick Off Protein Degrader Partnership

Sanofi Pays Kymera $150M to Kick Off Protein Degrader Partnership

Kymera Therapeutics has signed a deal with French biopharma Sanofi to advance two potential treatments for immune-inflammatory diseases that leverage the Cambridge, MA-based... Read more ...

Data Migration: Being Prepared

Data Migration: Being Prepared

Our Professional Services Written by: Alan Pham, Business Development Associate In a world where our data is crucial to our everyday lives, implementing new platforms is... Read more ...

NFlection Looks to Erase NF1 Tumors With Drug That Only Goes Skin Deep

NFlection Looks to Erase NF1 Tumors With Drug That Only Goes Skin Deep

The first drug for neurofibromatosis type 1 is available to patients following the FDA's approval of the AstraZeneca treatment earlier this year. Biotech startup NFlection... Read more ...

VelosBio Tacks on $137M to Advance Its ROR1-Targeting Cancer Antibody Drugs

VelosBio Tacks on $137M to Advance Its ROR1-Targeting Cancer Antibody Drugs

Dave Johnson has known UC San Diego physician and cancer reseacher Thomas Kipps for nearly 20 years. Now Johnson, CEO of San Diego-based cancer drug developer VelosBio, has... Read more ...

Biogen Alzheimer's Drug in FDA's Court Following Completion of Filing

Biogen Alzheimer's Drug in FDA's Court Following Completion of Filing

By early September Biogen-plus the many scientists, patients, and investors following the saga of its controversial Alzheimer's drug aducanamab-should know whether the FDA... Read more ...

The 2020 National Xconomy Awards Expands, Goes Virtual & Reopens Nomination...

The 2020 National Xconomy Awards Expands, Goes Virtual & Reopens Nomination Period

The 2020 National Xconomy Awards - celebrating the best in biotech innovation and entrepreneurship - just got bigger! We're excited to announce the expansion of the 2020... Read more ...

Scientists Dive Deep Into Hidden World of Quantum States

Scientists Dive Deep Into Hidden World of Quantum States

Right: Animation of a Van Hove singularity shown approximately 1 nanometer below the surface of an oxide heterostructure made of atomically thin layers of strontium titanate... Read more ...

UFGI Publication round-up week 7/6/20

Manipulation of sensory characteristics and volatile compounds in strawberry fruit through the use of isolated wavelengths of light. Campbell SM, Sims CA, Bartoshuk LM... Read more ...

DNA Chisel, a versatile sequence optimizer

AbstractMotivationAccounting for biological and practical requirements in DNA sequence design often results in challenging optimization problems. Current software solutions are... Read more ...