DEEPIMPUTE: AN ACCURATE, FAST, AND SCALABLE DEEP NEURAL NETWORK METHOD TO IMPUTE SINGLE-CELL RNA-SEQ DATA

Single-cell RNA sequencing offers new opportunities to study gene expression of tens of thousands of single cells simultaneously. We...

DISSOCIATION OF SOLID TUMOR TISSUES WITH COLD ACTIVE PROTEASE FOR SINGLE-CELL RNA-SEQ MINIMIZES CONSERVED COLLAGENASE-ASSOCIATED STRESS RESPONSES

Single-cell RNA sequencing is a powerful tool for studying complex biological systems, such as tumor heterogeneity and tissue microenvironments....

 
 
 

GLOBAL IMPACT OF SOMATIC STRUCTURAL VARIATION ON THE DNA METHYLOME OF HUMAN CANCERS

Genomic rearrangements exert a heavy influence on the molecular landscape of cancer. New analytical approaches integrating somatic...

BIRTH, EXPANSION, AND DEATH OF VCY-CONTAINING PALINDROMES ON THE HUMAN Y CHROMOSOME

Large palindromes make up substantial proportions of mammalian sex chromosomes, often contain genes, and have high rates of structural...

 
 
 

METACELL: ANALYSIS OF SINGLE-CELL RNA-SEQ DATA USING K-NN GRAPH PARTITIONS

ScRNA-seq profiles each represent a highly partial sample of mRNA molecules from a unique cell that can never be resampled, and robust...

IDENTIFYING SIGNIFICANTLY IMPACTED PATHWAYS: A COMPREHENSIVE REVIEW AND ASSESSMENT

Many high-throughput experiments compare two phenotypes such as disease vs. healthy, with the goal of understanding the underlying...

 
 
 

CORRECTION TO: AFRICAN EVOLUTIONARY HISTORY INFERRED FROM WHOLE GENOME SEQUENCE DATA OF 44 INDIGENOUS AFRICAN POPULATIONS

Following publication of the original article , a typographical error in the formula for calculating di in the “Scans for local adaptation”...

BENCHMARKING COMES OF AGE

 
 
 

CONVERGENCE OF HUMAN AND OLD WORLD MONKEY GUT MICROBIOMES DEMONSTRATES THE IMPORTANCE OF HUMAN ECOLOGY OVER PHYLOGENY

Comparative data from non-human primates provide insight into the processes that shaped the evolution of the human gut microbiome and...

BENCHMARK OF COMPUTATIONAL METHODS FOR PREDICTING MICRORNA-DISEASE ASSOCIATIONS

A series of miRNA-disease association prediction methods have been proposed to prioritize potential disease-associated miRNAs. Independent...

 
 
 

DIVERGENT NEURONAL DNA METHYLATION PATTERNS ACROSS HUMAN CORTICAL DEVELOPMENT REVEAL CRITICAL PERIODS AND A UNIQUE ROLE OF CPH METHYLATION

DNA methylation is a critical regulator of both development and cellular identity and shows unique patterns in neurons. To better characterize...

HOW TO MEET YOUR ‘SILENT PARTNER': TIPS FOR APPROACHING EDITORS AT CONFERENCES

 
 
 

QUANTITATIVE MNASE-SEQ ACCURATELY MAPS NUCLEOSOME OCCUPANCY LEVELS

Micrococcal nuclease is widely used to map nucleosomes. However, its aggressive endo-/exo-nuclease activities make MNase-seq unreliable...

WHEN THE LEVEE BREAKS: A PRACTICAL GUIDE TO SKETCHING ALGORITHMS FOR PROCESSING THE FLOOD OF GENOMIC DATA

Considerable advances in genomics over the past decade have resulted in vast amounts of data being generated and deposited in global...

 
 
 

THE FIRST ENHANCER IN AN ENHANCER CHAIN SAFEGUARDS SUBSEQUENT ENHANCER-PROMOTER CONTACTS FROM A DISTANCE

Robustness and evolutionary stability of gene expression in the human genome are established by an array of redundant enhancers.

REPRODUCIBLE BIOMEDICAL BENCHMARKING IN THE CLOUD: LESSONS FROM CROWD-SOURCED DATA CHALLENGES

Challenges are achieving broad acceptance for addressing many biomedical questions and enabling tool assessment. But ensuring that...

 
 
 

CUT&RUNTOOLS: A FLEXIBLE PIPELINE FOR CUT&RUN PROCESSING AND FOOTPRINT ANALYSIS

We introduce CUT&RUNTools as a flexible, general pipeline for facilitating the identification of chromatin-associated protein binding...

SCBFA: MODELING DETECTION PATTERNS TO MITIGATE TECHNICAL NOISE IN LARGE-SCALE SINGLE-CELL GENOMICS DATA

Technical variation in feature measurements, such as gene expression and locus accessibility, is a key challenge of large-scale single-cell...

 
 
 

A COMPARISON OF AUTOMATIC CELL IDENTIFICATION METHODS FOR SINGLE-CELL RNA SEQUENCING DATA

Single-cell transcriptomics is rapidly advancing our understanding of the cellular composition of complex tissues and organisms. A...

EXPANDING THE SCOPE AND SCALE OF MICROBIOME RESEARCH

 
 
 



World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

SeaGen to Seek FDA Nod After Breast Cancer Drug Hits Goals of Key Study

SeaGen to Seek FDA Nod After Breast Cancer Drug Hits Goals of Key Study

An experimental breast cancer drug from Seattle Genetics is headed for FDA review after the company reported a pivotal clinical trial met its main goals. The company has been... Read more ...

Backed by $50M, Verseau Launches to Reprogram Immune Cells Against Cancer

Backed by $50M, Verseau Launches to Reprogram Immune Cells Against Cancer

Cancer therapies that harness the immune system don't work for all patients. Verseau Therapeutics aims to bring cancer immunotherapy to more people by targeting a type of... Read more ...

The secret of classic Belgian beers? Medieval super-yeasts

An international team of scientists led by Prof. Kevin Verstrepen and Prof. Steven Maere has discovered that some of the most renowned classic Belgian beers, including Gueuze... Read more ...

Edible grasshoppers can be modified for better fatty acid composition

It is possible to modify the fatty acid composition of edible grasshoppers by adding essential fatty acids in their feed, new research from the University of Eastern Finland... Read more ...

Manager, Engineering - Bachem - Vista, CA

The company provides a full range of services to the pharma and biotech industries. Handle complete project life cycle from design, planning and implementation...From Bachem... Read more ...

Bayer backs off running Casebia JV, as CRISPR Tx takes over management

Three years after Bayer and gene-editing biotech CRISPR Therapeutics joined forces to launch and run Casebia Therapeutics, the German Pharma is now handing over the full reins... Read more ...

Uncovering the principles behind RNA folding

Using high-throughput next-generation sequencing technology, a researcher found similarities in the folding tendencies among a family of RNA molecules called riboswitches... Read more ...

Listening in to how proteins talk and learning their language

A research team has created a third approach to engineering proteins that uses deep learning to distill the fundamental features of proteins directly from their amino acid... Read more ...

Pinpointing biomolecules with nanometer accuracy

Scientists demonstrate a new approach in fluorescence microscopy that can be used to locate individual biomolecules in 3D space with nanometer-scale precision. Read more ...

How the mouse X and Y chromosomes compete with each other to control offspring

New research presents the first demonstration of a specific difference in sperm function associated with sex ratio skewing. Read more ...