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BMC Bioinformatics

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ACCUCOPY: ACCURATE AND FAST INFERENCE OF ALLELE-SPECIFIC COPY NUMBER ALTERATIONS FROM LOW-COVERAGE LOW-PURITY TUMOR SEQUENCING DATA

Copy number alterations , due to their large impact on the genome, have been an important contributing factor to oncogenesis and metastasis....

DRUG PERTURBATION GENE SET ENRICHMENT ANALYSIS : A NEW TRANSCRIPTOMIC DRUG SCREENING APPROACH

In this study, we demonstrate that our modified Gene Set Enrichment Analysis method, drug perturbation GSEA , can detect phenotypically...

 
 
 

IMPACT OF EXPLICIT AREA SCALING ON KINETIC MODELS INVOLVING MULTIPLE COMPARTMENTS

Computational modelling of cell biological processes is a frequently used technique to analyse the underlying mechanisms and to generally...

H2V: A DATABASE OF HUMAN GENES AND PROTEINS THAT RESPOND TO SARS-COV-2, SARS-COV, AND MERS-COV INFECTION

The ongoing global COVID-19 pandemic is caused by SARS-CoV-2, a novel coronavirus first discovered at the end of 2019. It has led to...

 
 
 

IDENTIFYING THE SEQUENCE SPECIFICITIES OF CIRCRNA-BINDING PROTEINS BASED ON A CAPSULE NETWORK ARCHITECTURE

Circular RNAs are widely expressed in cells and tissues and are involved in biological processes and human diseases. Recent studies...

PYCONVU-NET: A LIGHTWEIGHT AND MULTISCALE NETWORK FOR BIOMEDICAL IMAGE SEGMENTATION

With the development of deep learning , more and more methods based on deep learning are proposed and achieve state-of-the-art performance...

 
 
 

PREDICTING CHEMOSENSITIVITY USING DRUG PERTURBED GENE DYNAMICS

One of the current directions of precision medicine is the use of computational methods to aid in the diagnosis, prognosis, and treatment...

G-TRIC: GENERATING THREE-WAY SYNTHETIC DATASETS WITH TRICLUSTERING SOLUTIONS

Three-way data started to gain popularity due to their increasing capacity to describe inherently multivariate and temporal events,...

 
 
 

MODELING DRUG MECHANISM OF ACTION WITH LARGE SCALE GENE-EXPRESSION PROFILES USING GPAR, AN ARTIFICIAL INTELLIGENCE PLATFORM

Querying drug-induced gene expression profiles with machine learning method is an effective way for revealing drug mechanism of actions...

SCC: AN ACCURATE IMPUTATION METHOD FOR SCRNA-SEQ DROPOUTS BASED ON A MIXTURE MODEL

Single-cell RNA sequencing enables the possibility of many in-depth transcriptomic analyses at a single-cell resolution. It's already...

 
 
 

MATHLA: A ROBUST FRAMEWORK FOR HLA-PEPTIDE BINDING PREDICTION INTEGRATING BIDIRECTIONAL LSTM AND MULTIPLE HEAD ATTENTION MECHANISM

Accurate prediction of binding between class I human leukocyte antigen and neoepitope is critical for target identification within...

DISTEVAL: A WEB SERVER FOR EVALUATING PREDICTED PROTEIN DISTANCES

Protein inter-residue contact and distance prediction are two key intermediate steps essential to accurate protein structure prediction....

 
 
 

PCIRC: RANDOM FOREST-BASED PLANT CIRCRNA IDENTIFICATION SOFTWARE

Circular RNA is a novel type of RNA with a closed-loop structure. Increasing numbers of circRNAs are being identified in plants and...

DRUG-INDUCED CELL VIABILITY PREDICTION FROM LINCS-L1000 THROUGH WRFEN-XGBOOST ALGORITHM

Predicting the drug response of the cancer diseases through the cellular perturbation signatures under the action of specific compounds...

 
 
 

PROPEDIA: A DATABASE FOR PROTEIN-PEPTIDE IDENTIFICATION BASED ON A HYBRID CLUSTERING ALGORITHM

Protein-peptide interactions play a fundamental role in a wide variety of biological processes, such as cell signaling, regulatory...

C-NORM: A NEURAL APPROACH TO FEW-SHOT ENTITY NORMALIZATION

Entity normalization is an important information extraction task which has gained renewed attention in the last decade, particularly...

 
 
 

DEPENDENCY PARSING OF BIOMEDICAL TEXT WITH BERT

Syntactic analysis, or parsing, is a key task in natural language processing and a required component for many text mining approaches....

AN AUTOMATED PROTOCOL FOR MODELLING PEPTIDE SUBSTRATES TO PROTEASES

Proteases are key drivers in many biological processes, in part due to their specificity towards their substrates. However, depending...

 
 
 

CONVEX HULLS IN HAMMING SPACE ENABLE EFFICIENT SEARCH FOR SIMILARITY AND CLUSTERING OF GENOMIC SEQUENCES

In molecular epidemiology, comparison of intra-host viral variants among infected persons is frequently used for tracing transmissions...

MULTI-VIEW FEATURE SELECTION FOR IDENTIFYING GENE MARKERS: A DIVERSIFIED BIOLOGICAL DATA DRIVEN APPROACH

In recent years, to investigate challenging bioinformatics problems, the utilization of multiple genomic and proteomic sources has...

 
 
 



World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

PacBio and Invitae Team Up to Develop Ultra-High-Throughput Clinical Whole...

PacBio and Invitae Team Up to Develop Ultra-High-Throughput Clinical Whole Genome Sequencing Platform

The power of PacBio HiFi reads has enabled transformative research into human disease. A new collaboration with Invitae, a leader in medical genetics, is intended to help... Read more ...

STAT: Businesses across the vaccine supply chain must work together to make...

STAT: Businesses across the vaccine supply chain must work together to make Covid-19 vaccines

Andrey Zarur, CEO of GreenLight Biosciences, writes for STAT about the vaccine supply chain and how we need to work together to make Covid-19 vaccines. Credit: LEON NEAL/GETTY... Read more ...

IAmScience Leland Cseke

IAmScience Leland Cseke

By Becca Wolf | Bond LSC In a cluttered basement in Dearborn, Michigan, one could find Leland Cseke conducting amateur plant tissue culture experiments on his family's pool... Read more ...

Study: X-Rays Surrounding ‘Magnificent 7' May Be Traces of Sought-After Particle

Study: X-Rays Surrounding ‘Magnificent 7' May Be Traces of Sought-After Particle

An artistic rendering of the XMM-Newton space telescope. A study of archival data from the XMM-Newton and the Chandra X-ray space telescopes found evidence of high levels of... Read more ...

AnaptysBio, Inc.: Senior Scientist II

AnaptysBio, Inc.: Position Summary The candidate will play a lead role in Protein Sciences, with responsibilities to include the supervision of protein purification an San... Read more ...

Emergent BioSolutions: Senior Manager, Product Development

Emergent BioSolutions: Those who join Emergent BioSolutions feel a sense of ownership about their future. You will excel in an environment characterized by respect... Read more ...

MendelVar: gene prioritisation at GWAS loci using phenotypic enrichment of...

AbstractMotivationGene prioritisation at human GWAS loci is challenging due to linkage disequilibrium and long-range gene regulatory mechanisms. However, identifying the causal... Read more ...

A two-step approach to testing overall effect of gene-environment...

AbstractMotivationWhile gene-environment interactions contribute importantly to many different phenotypes, detecting such interactions requires well-powered studies and has... Read more ...

A network-based deep learning methodology for stratification of tumor mutations

AbstractMotivationTumor stratification has a wide range of biomedical and clinical applications, including diagnosis, prognosis and personalized treatment. However, cancer is... Read more ...

Recognition of small molecule-RNA binding sites using RNA sequence and structure

AbstractMotivationRNA molecules become attractive small-molecule drug targets to treat disease in recent years. Computer-aided drug design can be facilitated by detecting the... Read more ...