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BMC Bioinformatics

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THEORETICAL CHARACTERISATION OF STRAND CROSS-CORRELATION IN CHIP-SEQ

Strand cross-correlation profiles are used for both peak calling pre-analysis and quality control in chromatin immunoprecipitation...

AN EMBEDDED GENE SELECTION METHOD USING KNOCKOFFS OPTIMIZING NEURAL NETWORK

Gene selection refers to find a small subset of discriminant genes from the gene expression profiles. How to select genes that affect...

 
 
 

SAPPHIRE: A NEURAL NETWORK BASED CLASSIFIER FOR Σ70 PROMOTER PREDICTION IN PSEUDOMONAS

In silico promoter prediction represents an important challenge in bioinformatics as it provides a first-line approach to identifying...

MAPGL: INFERRING EVOLUTIONARY GAIN AND LOSS OF SHORT GENOMIC SEQUENCE FEATURES BY PHYLOGENETIC MAXIMUM PARSIMONY

Comparative genomics studies are growing in number partly because of their unique ability to provide insight into shared and divergent...

 
 
 

KEEPING UP WITH THE GENOMES: EFFICIENT LEARNING OF OUR INCREASING KNOWLEDGE OF THE TREE OF LIFE

It is a computational challenge for current metagenomic classifiers to keep up with the pace of training data generated from genome...

PREDICTION OF HOT SPOTS IN PROTEIN-DNA BINDING INTERFACES BASED ON SUPERVISED ISOMETRIC FEATURE MAPPING AND EXTREME GRADIENT BOOSTING

Identification of hot spots in protein-DNA interfaces provides crucial information for the research on protein-DNA interaction and...

 
 
 

NEDD: A NETWORK EMBEDDING BASED METHOD FOR PREDICTING DRUG-DISEASE ASSOCIATIONS

Drug discovery is known for the large amount of money and time it consumes and the high risk it takes. Drug repositioning has, therefore,...

MULTI-OMICS PROFILING REVEALS MICRORNA-MEDIATED INSULIN SIGNALING NETWORKS

MicroRNAs play a key role in mediating the action of insulin on cell growth and the development of diabetes. However, few studies have...

 
 
 

A LEARNING-BASED METHOD FOR DRUG-TARGET INTERACTION PREDICTION BASED ON FEATURE REPRESENTATION LEARNING AND DEEP NEURAL NETWORK

Drug-target interaction prediction is of great significance for narrowing down the scope of candidate medications, and thus is a vital...

PAWER: PROTEIN ARRAY WEB EXPLORER

Protein microarray is a well-established approach for characterizing activity levels of thousands of proteins in a parallel manner....

 
 
 

AN IMPROVEMENT OF COMIR ALGORITHM FOR MICRORNA TARGET PREDICTION BY EXPLOITING CODING REGION SEQUENCES OF MRNAS

MicroRNA are small non-coding RNAs that post-transcriptionally regulate the expression levels of messenger RNAs. MicroRNA regulation...

A PRELIMINARY PET RADIOMICS STUDY OF BRAIN METASTASES USING A FULLY AUTOMATIC SEGMENTATION METHOD

Positron Emission Tomography is increasingly utilized in radiomics studies for treatment evaluation purposes. Nevertheless, lesion...

 
 
 

BITS2019: THE SIXTEENTH ANNUAL MEETING OF THE ITALIAN SOCIETY OF BIOINFORMATICS

The 16th Annual Meeting of the Bioinformatics Italian Society was held in Palermo, Italy, on June 26-28, 2019. More than 80 scientific...

CORRECTION TO: FASTMM: AN EFFICIENT TOOLBOX FOR PERSONALIZED CONSTRAINT-BASED METABOLIC MODELING

An amendment to this paper has been published and can be accessed via the original article.

 
 
 

MEIRLOP: IMPROVING SCORE-BASED MOTIF ENRICHMENT BY INCORPORATING SEQUENCE BIAS COVARIATES

Motif enrichment analysis identifies over-represented transcription factor binding motifs in the DNA sequence of regulatory regions,...

ADEPT: A DOMAIN INDEPENDENT SEQUENCE ALIGNMENT STRATEGY FOR GPU ARCHITECTURES

Bioinformatic workflows frequently make use of automated genome assembly and protein clustering tools. At the core of most of these...

 
 
 

SEAGULL: LASSO, GROUP LASSO AND SPARSE-GROUP LASSO REGULARIZATION FOR LINEAR REGRESSION MODELS VIA PROXIMAL GRADIENT DESCENT

Statistical analyses of biological problems in life sciences often lead to high-dimensional linear models. To solve the corresponding...

LIMIT CYCLES IN MODELS OF CIRCULAR GENE NETWORKS REGULATED BY NEGATIVE FEEDBACK LOOPS

The regulatory feedback loops that present in structural and functional organization of molecular-genetic systems and the phenomenon...

 
 
 

ON THE DYNAMICAL ASPECTS OF LOCAL TRANSLATION AT THE ACTIVATED SYNAPSE

The key role in the dynamic regulation of synaptic protein turnover belongs to the Fragile X Mental Retardation Protein, which regulates...

REVIEW OF MEDICAL IMAGE RECOGNITION TECHNOLOGIES TO DETECT MELANOMAS USING NEURAL NETWORKS

Melanoma is one of the most aggressive types of cancer that has become a world-class problem. According to the World Health Organization...

 
 
 



World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Bio Roundup: Grail Acquisition, Libra's Launch, Tau Trial Results & More

Bio Roundup: Grail Acquisition, Libra's Launch, Tau Trial Results & More

In biotech, you can go home again. Four years ago, Illumina spun out cancer diagnostics startup Grail. This week, the gene sequencing giant announced it is acquiring Grail in... Read more ...

Combined Therapeutics Wins $250,000 MilliporeSigma Advance Biotech Grant

Combined Therapeutics Wins $250,000 MilliporeSigma Advance Biotech Grant

MilliporeSigma has awarded MIT spin-out Combined Therapeutics a check for $250,000 as the winner of its 2020 Advance Biotech Grant. Combined Therapeutics is an early stage... Read more ...

Machine Learning Takes on Synthetic Biology: Algorithms Can Bioengineer...

Machine Learning Takes on Synthetic Biology: Algorithms Can Bioengineer Cells for You

Tijana Radivojevic and Hector Garcia Martin working on mechanical and statistical modeling, data visualizations, and metabolic maps at the Agile BioFoundry last year. If... Read more ...

And the 2020 National Xconomy Awards Winners Are

And the 2020 National Xconomy Awards Winners Are

Congratulations to all the finalists and winners! This year we received over 600 nominations across 10 award categories. Each nomination was carefully reviewed and ranked by... Read more ...

Talking Alone: Researchers Use Artificial Intelligence Tools to Predict...

Talking Alone: Researchers Use Artificial Intelligence Tools to Predict Loneliness

A team led by researchers at University of California San Diego School of Medicine has used artificial intelligence technologies to analyze natural language patterns to discern... Read more ...

Monte Rosa Raises $96M for “Glue-Based” Protein Degrading Drugs

Monte Rosa Raises $96M for “Glue-Based” Protein Degrading Drugs

Many drugs work by binding to a protein and blocking it. Technology for eliminating disease-causing proteins altogether remains experimental, but this approach has gained... Read more ...

Libra Strikes a Balance With Approach to ALS and Other Neuro Disorders

Libra Strikes a Balance With Approach to ALS and Other Neuro Disorders

Amyotrophic lateral sclerosis has no cure and few available treatments but the past decade has revealed new knowledge about the pathology of the disease. Libra Therapeutics is... Read more ...

Scientists sequence the 92-year-old mold that produced the first antibiotic...

This mold was regrown from Alexander Fleming's frozen sample that produced the first antibiotic, penicillin. Read more ...

What We Know About Coronavirus Cases in K-12 Schools So Far

Schools are not islands, and so it was inevitable that when students and teachers returned this fall to classrooms, coronavirus cases would follow them. Read more ...

Cidara Therapeutics: Senior Clinical Data Manager

Cidara Therapeutics: Position Summary The Senior Clinical Data Manager is responsible for performing data management vendor oversight, complex clinical data review, dis... San... Read more ...