MOLECULAR BASIS FOR ARGININE C-TERMINAL DEGRON RECOGNITION BY CUL2 FEM1 E3 LIGASE
Nature Chemical Biology, Published online: 04 January 2021; doi:10.1038/s41589-020-00704-3 Structural characterization of the substrate...
BOTTOM-UP DE NOVO DESIGN OF FUNCTIONAL PROTEINS WITH COMPLEX STRUCTURAL FEATURES
Nature Chemical Biology, Published online: 04 January 2021; doi:10.1038/s41589-020-00699-x Beginning with a functional site and building...
MOLECULAR BASIS FOR UBIQUITIN LIGASE CRL2 FEM1C -MEDIATED RECOGNITION OF C-DEGRON
Nature Chemical Biology, Published online: 04 January 2021; doi:10.1038/s41589-020-00703-4 Crystal structures of FEM1C in apo and in...
CONFORMATIONAL REARRANGEMENT DURING ACTIVATION OF A METABOTROPIC GLUTAMATE RECEPTOR
Nature Chemical Biology, Published online: 04 January 2021; doi:10.1038/s41589-020-00702-5 Single-molecule FRET of mGluR2 shows that...
LIVING MATERIALS FABRICATED VIA GRADIENT MINERALIZATION OF LIGHT-INDUCIBLE BIOFILMS
Nature Chemical Biology, Published online: 21 December 2020; doi:10.1038/s41589-020-00697-z Coupling light-inducible bacterial biofilm...
CONTROLLING AND ENHANCING CRISPR SYSTEMS
Nature Chemical Biology, Published online: 16 December 2020; doi:10.1038/s41589-020-00700-7 This Review summarizes recent advances...
VOICES OF CHEMICAL BIOLOGY
Nature Chemical Biology, Published online: 16 December 2020; doi:10.1038/s41589-020-00714-1 We asked a collection of chemical biologists,...
CALL FOR NOMINATIONS: ACS INFECTIOUS DISEASES YOUNG INVESTIGATOR AWARD
The ACS Infectious Diseases Young Investigator Award is a collaboration between ACS Infectious Diseases and the ACS Division of Biological...
AUTHOR CORRECTION: ION CHANNELS AS LIPID SENSORS: FROM STRUCTURES TO MECHANISMS
Nature Chemical Biology, Published online: 17 December 2020; doi:10.1038/s41589-020-00722-1 Author Correction: Ion channels as lipid...
DECEMBER 2020 NEWSLETTER RELEASED!
The December 2020 newsletter was just released. BIOL members should have received it in their email. You can find the newsletter here...
LINKAGE-SPECIFIC UBIQUITIN CHAIN FORMATION DEPENDS ON A LYSINE HYDROCARBON RULER
Nature Chemical Biology, Published online: 07 December 2020; doi:10.1038/s41589-020-00696-0 Using synthetic ubiquitins with non-natural...
PIEZO1 ACTS UPSTREAM OF TRPV4 TO INDUCE PATHOLOGICAL CHANGES IN ENDOTHELIAL CELLS DUE TO SHEAR STRESS
The ion channels Piezo1 and TRPV4 have both, independently, been implicated in high venous pressure- and fluid shear stress-induced...
CRYPTIC PHOSPHORYLATION IN NUCLEOSIDE NATURAL PRODUCT BIOSYNTHESIS
Nature Chemical Biology, Published online: 30 November 2020; doi:10.1038/s41589-020-00656-8 Rather than their expected role in self-immunity,...
CHEMICALLY INFORMED ANALYSES OF METABOLOMICS MASS SPECTROMETRY DATA WITH QEMISTREE
Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00677-3 Qemistree uses fragmentation spectra to...
ION CHANNELS AS LIPID SENSORS: FROM STRUCTURES TO MECHANISMS
Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00693-3 Ion channel structures reveal mechanisms...
CELL TYPE-SELECTIVE SECRETOME PROFILING IN VIVO
Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00698-y A proximity labeling strategy enables enrichment...
DEFINING NEW CHEMICAL SPACE FOR DRUG PENETRATION INTO GRAM-NEGATIVE BACTERIA
Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00674-6 The difficulty of antibiotic discovery...
SNAPSHOTS AND ENSEMBLES OF BTK AND CIAP1 PROTEIN DEGRADER TERNARY COMPLEXES
Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00686-2 The authors report PROTAC ternary complex...
THE CONFORMATIONAL CYCLE OF A PROTOTYPICAL VOLTAGE-GATED SODIUM CHANNEL
Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-0644-4 The conformational cycle of a bacterial...
DELIMITING LIPIDS
Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00701-6 This themed issue features a collection...
World Biotechnology Congress 2019
Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...
World Biotechnology Congress 2019
Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...
2nd International Conference on Tissue Science and Regenerative Medicine
This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...
PacBio and Invitae Team Up to Develop Ultra-High-Throughput Clinical Whole...
The power of PacBio HiFi reads has enabled transformative research into human disease. A new collaboration with Invitae, a leader in medical genetics, is intended to help... Read more ...
STAT: Businesses across the vaccine supply chain must work together to make...
Andrey Zarur, CEO of GreenLight Biosciences, writes for STAT about the vaccine supply chain and how we need to work together to make Covid-19 vaccines. Credit: LEON NEAL/GETTY... Read more ...
IAmScience Leland Cseke
By Becca Wolf | Bond LSC In a cluttered basement in Dearborn, Michigan, one could find Leland Cseke conducting amateur plant tissue culture experiments on his family's pool... Read more ...
Study: X-Rays Surrounding ‘Magnificent 7' May Be Traces of Sought-After Particle
An artistic rendering of the XMM-Newton space telescope. A study of archival data from the XMM-Newton and the Chandra X-ray space telescopes found evidence of high levels of... Read more ...
AnaptysBio, Inc.: Senior Scientist II
AnaptysBio, Inc.: Position Summary The candidate will play a lead role in Protein Sciences, with responsibilities to include the supervision of protein purification an San... Read more ...
Emergent BioSolutions: Senior Manager, Product Development
Emergent BioSolutions: Those who join Emergent BioSolutions feel a sense of ownership about their future. You will excel in an environment characterized by respect... Read more ...
MendelVar: gene prioritisation at GWAS loci using phenotypic enrichment of...
AbstractMotivationGene prioritisation at human GWAS loci is challenging due to linkage disequilibrium and long-range gene regulatory mechanisms. However, identifying the causal... Read more ...
A two-step approach to testing overall effect of gene-environment...
AbstractMotivationWhile gene-environment interactions contribute importantly to many different phenotypes, detecting such interactions requires well-powered studies and has... Read more ...
A network-based deep learning methodology for stratification of tumor mutations
AbstractMotivationTumor stratification has a wide range of biomedical and clinical applications, including diagnosis, prognosis and personalized treatment. However, cancer is... Read more ...
Recognition of small molecule-RNA binding sites using RNA sequence and structure
AbstractMotivationRNA molecules become attractive small-molecule drug targets to treat disease in recent years. Computer-aided drug design can be facilitated by detecting the... Read more ...