Therapeutics

PacBio-Powered Analysis Indicates Methylation Makes TB Pathogen So Wily

1 month ago   |   By Pacific Biosciences

Scientists have long struggled to explain the success of Mycobacterium tuberculosis in the face of effective therapeutics. Tuberculosis kills more than 1 million people annually, and has a remarkable ability to develop resistance to drugs despite its stable genome. But now, a new study from researchers at San Diego State University and other institutions strongly suggests that methylation rather than genome sequence gives M. tuberculosis its broad phenotypic range.
Lead author Samuel Modlin , senior author Faramarz Valafar , and collaborators report using SMRT Sequencing technology to...
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