Chemical

Chemically informed analyses of metabolomics mass spectrometry data with Qemistree

1 month ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00677-3 Qemistree uses fragmentation spectra to predict molecular fingerprints and represent their relationships as a tree, enabling comparison of metabolomics data across different experimental conditions and exploration of chemical diversity in mixtures.
Read more ...

 

Ion channels as lipid sensors: from structures to mechanisms

1 month ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00693-3 Ion channel structures reveal mechanisms of lipid action, including how channel gating is altered by direct binding of signaling lipids and those within the membrane itself, as well as mechanical and architectural effects of membrane lipids.
Read more ...

 

Cell type-selective secretome profiling in vivo

1 month ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00698-y A proximity labeling strategy enables enrichment of cell type-selective secretomes in mice by direct biochemical purification of biotinylated polypeptides from blood plasma.
Read more ...

 

Defining new chemical space for drug penetration into Gram-negative bacteria

1 month ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00674-6 The difficulty of antibiotic discovery posed by the double-membrane cell envelope of Gram-negative bacteria and active drug efflux requires better understanding of bacterial permeability and compound accumulation, and more diverse chemical libraries.
Read more ...

 

Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes

1 month ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00686-2 The authors report PROTAC ternary complex structures involving the E3 ligase cIAP1 and target protein BTK, showing that cooperativity is not always correlated with degradation efficiency.
Read more ...

 

The conformational cycle of a prototypical voltage-gated sodium channel

1 month ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-0644-4 The conformational cycle of a bacterial voltage-gated sodium channel as it transitions from resting to activated open to inactivated closed states can be constructed from various crystal structure snapshots.
Read more ...

 

Delimiting lipids

1 month ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00701-6 This themed issue features a collection of articles that explore long-standing questions in the study of lipids and membranes.
Read more ...

 

Making use of surplus sugar

1 month ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00687-1 Insects have many ways of disabling plant chemical defenses during feeding. Plant phloem feeders use surplus ingested sugar to block the activation of glucosinolate toxins, providing a target for precise resistance breeding.
Read more ...

 


Search by Tags

   Chemical      Chemicals      Biological      Nature      Biology      Biologic      Nat Chem Biol      Publications      Biochemical      Drugs      Drug      Antibiotics      Discovery      Protein      Feed      Plants  


World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

PacBio-Powered Analysis Indicates Methylation Makes TB Pathogen So Wily

PacBio-Powered Analysis Indicates Methylation Makes TB Pathogen So Wily

Scientists have long struggled to explain the success of Mycobacterium tuberculosis in the face of effective therapeutics. Tuberculosis kills more than 1 million people... Read more ...

Latin America Expansion

Latin America Expansion

We're growing! At PSC Biotech Corporation, we take great pleasure in announcing that, in light of our remarkable continuous growth over the last several years, we are expanding... Read more ...

Case Study | How Thermo Fisher Scientific Streamlined Inspection Management...

Case Study | How Thermo Fisher Scientific Streamlined Inspection Management With AuditUtopia®

Our Software Solutions Read more ...

BCI Society Workshop: On the need of good practices and standards for...

Translating Brain-Machine Interfacing systems outside research laboratories onto real applications requires reliable measurement of their performance. However, there are no... Read more ...

Research Associate I Bodmer Lab - Sanford Burnham Prebys Medical Discovery...

Sanford Burnham Prebys is a preeminent, independent biomedical research institute dedicated to understanding human biology and disease, and advancing scientific...From Sanford... Read more ...

107444 Lead Survey Worker - Bilingual English/Korean

CANCER CENTER Salary commensurate with qualifications and experienceFiling Deadline: Thu 2/4/2021... Read more ...

Senior Scientist, Pharmaceutical Development - Ionis Pharmaceuticals, Inc...

The candidate will have a good understanding of the drug development process and technical experience in parenteral manufacturing is a plus, particularly...From Ionis... Read more ...

Senior Manager, Biostatistician - Bristol Myers Squibb - San Diego, CA

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. We bring a human touch to every treatment we pioneer...From... Read more ...

Inside TSS Cell Culture - Thermo Fisher Scientific - San Diego, CA

Inside Sales Representative - Cell Culture Specialist. When you are part of the team at Thermo Fisher Scientific, you'll do important work and you'll be valued...From Thermo... Read more ...

Novel effector biology research provides insights into devastating citrus...

Citrus greening disease, also known as Huanglongbing , is devastating to the citrus industry, causing unprecedented amounts of damage worldwide. There is no known cure. Since... Read more ...