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DeepCDA: Deep Cross-Domain Compound-Protein Affinity Prediction through LSTM and Convolutional Neural Networks

1 day ago   |   Oxford Journals

AbstractMotivationAn essential part of drug discovery is the accurate prediction of the binding affinity of new compound-protein pairs. Most of the standard computational...
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Fuzzy linear programming problems: models and solutions

2 days ago   |   Springer

Abstract We investigate various types of fuzzy linear programming problems based on models and solution methods. First, we review fuzzy linear programming problems with fuzzy...
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Multiobjective evolutionary-based multi-kernel learner for realizing transfer learning in the prediction of HIV-1 protease cleavage sites

2 days ago   |   Springer

Abstract Due to the unavailability of adequate patients and expensive labeling cost, many real-world biomedical cases have scarcity in the annotated data. This holds very true...
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Gilead Gains Foothold in Solid Tumors With $375M, 10-Year Arcus Bio Pact

Gilead Gains Foothold in Solid Tumors With $375M, 10-Year Arcus Bio Pact

3 days ago   |   Xconomy

With the year's biggest oncology conference days away, Gilead Sciences is signaling now what its cancer immunotherapy pipeline could look like in the years to come. The drug...
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Superior haplotypes for haplotype‐based breeding for drought tolerance in pigeonpea

3 days ago   |   Wiley

Abstract Haplotype‐based breedin g, a recent promising breeding approach to develop tailored made crop varieties deals with identification of superior haplotypes and their...
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Merck Outlines COVID-19 Ambitions With Buyout Deal, Collaborations

Merck Outlines COVID-19 Ambitions With Buyout Deal, Collaborations

3 days ago   |   Xconomy

Merck exited the holiday weekend with some fireworks of its own, announcing three major programs on Tuesday all related to investments in finding ways to treat and prevent...
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Molecular Targets for the Testing of COVID‐19

Molecular Targets for the Testing of COVID‐19

5 days ago   |   Wiley   |   2 articles

RNA and proteins of a Betacoronavirus virion as well as virus induced antibodies can be used as molecular biomarkers for viral infection. This paper describes the principle of...
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Generation Bio Leads a Trio of Biotech Companies Aiming for the Nasdaq

Generation Bio Leads a Trio of Biotech Companies Aiming for the Nasdaq

7 days ago   |   Xconomy

COVID-19 has ravaged the economy, and it was expected to quash the IPO market, too. But the biotech sector is defying the pandemic with crossover financings and freshly minted...
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Bio Roundup: mRNA Vaccine Data, Rise of Rallybio, Roche's Protein Play & More

Bio Roundup: mRNA Vaccine Data, Rise of Rallybio, Roche's Protein Play & More

8 days ago   |   Xconomy

As the nation started to reopen this week following two months of closed businesses and stay-at-home orders, public health officials and economists cautioned that society won't...
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Restructured Melinta now wants to buy fellow antibiotic maker Tetraphase; TA Associates mulls $500M deal for a stake in CDMO

8 days ago   |   San Diego Biotechnology

? Yet another buyer has emerged in what is shaping up to be a bidding war for Tetraphase and its marketed antibiotic. Melinta - a fellow antibiotics maker that's freshly...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Forma Therapeutics Eyes IPO to Advance Sickle Cell, Prostate Cancer Drugs

Forma Therapeutics Eyes IPO to Advance Sickle Cell, Prostate Cancer Drugs

Forma Therapeutics has developed a pipeline of small molecules aimed at rare blood disorders and cancers, but it aims to advance two-investigational treatments for sickle cell... Read more ...

Bio Roundup: ASCO Opens, Merck Takes On COVID, Evofem's Approval & More

Bio Roundup: ASCO Opens, Merck Takes On COVID, Evofem's Approval & More

A year ago about 40,000 people gathered in Chicago for the annual meeting of the American Society of Clinical Oncology. Today a virtual version of the ASCO conference, the... Read more ...

AbbVie Wins First FDA Approval of Drug to Treat Uterine Fibroid Bleeds

AbbVie Wins First FDA Approval of Drug to Treat Uterine Fibroid Bleeds

An AbbVie drug that treats pain in the uterus has notched an additional FDA approval for addressing heavy menstrual bleeding associated with uterine fibroids. The regulatory... Read more ...

Daya Bay Reactor Experiment Continues to Generate Data

Daya Bay Reactor Experiment Continues to Generate Data

Antineutrino detectors are submersed in liquid at the Daya Bay experiment, as seen during the final phase of construction in August 2012. Experiment: Daya Bay reactor neutrino... Read more ...

Seeing Cancer, But Not Through a Microscope

Seeing Cancer, But Not Through a Microscope

Toward the end of the 19th century, a French doctor named Ernest Besnier coined the term “ biopsy ,” combining the Greek bios and opsis. In the decades since, clinicians have... Read more ...

Variant Emerges With $16M to Find “Outlier Humans” to Reveal New Drugs

Variant Emerges With $16M to Find “Outlier Humans” to Reveal New Drugs

Human DNA holds secrets that, once uncovered, have led scientists to develop a number of treatments for disease. A slew of biopharmas and biotechs-not to mention national... Read more ...

Don't Wait for “Them” to Find Your Weaknesses

Don't Wait for “Them” to Find Your Weaknesses

Our Professional Services Written by: Crystal Booth, M.M.- Regional Manager, Southeast USA at PSC Biotech We've probably all heard the phrase “audit ready state”. But what does... Read more ...

Functional oral nanoparticles for delivering silibinin and cryptotanshinone...

Breast cancer lung metastasis occurs in more than 60% of all patients with breast cancer, and most of those afflicted by it eventually die of recurrence. The tumor... Read more ...

Escherichia coli metabolism under short-term repetitive substrate dynamics...

Microbial metabolism is highly dependent on the environmental conditions. Especially, the substrate concentration, as well as oxygen availability, determine the metabolic... Read more ...

High-yield production of l-serine through a novel identified exporter...

L-Serine has wide and increasing applications in industries with fast-growing market demand. Although strategies for achieving and improving l-serine production in... Read more ...