Computers

Computational design of G Protein-Coupled Receptor allosteric signal transductions

11 monthes ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 02 December 2019; doi:10.1038/s41589-019-0407-2 A computational approach for designing GPCRs with new signaling functions including allosteric signaling properties yielded D2 receptor variants with predictable G-protein signaling responses, some with enhanced potency and responses to dopamine.
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Guided nuclear exploration increases CTCF target search efficiency

11 monthes ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 02 December 2019; doi:10.1038/s41589-019-0422-3 Single-particle tracking and mathematical modeling methods reveal the searching mechanism of CTCF for its cognate sites on DNA. An RNA-binding region in CTCF mediates its trapping in small zones and increases its target search efficiency.
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Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development

11 monthes ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 02 December 2019; doi:10.1038/s41589-019-0415-2 The cellular stability of an oncogenic factor, AIMP2-DX2, is increased via association with HSP70. Interference with this interaction by a small-molecule compound promotes ubiquitin-mediated degradation of AIMP2-DX2 and reduces cancer cell growth.
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Resilient living materials built by printing bacterial spores

11 monthes ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 02 December 2019; doi:10.1038/s41589-019-0412-5 3D printing agarose hydrogels embedded with Bacillus subtilis spores produce custom-shaped materials that are resistant to environmental stresses, while the bacteria maintain the ability to germinate on the surface and respond to stimuli.
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Asso Scientist Digital Pathology Solutions Novartis/Navigate BioPharma...

Analyze and QC of image data using AQUA® Technology or Halo image analysis software. Data report and data transfer using LIMS. What you will bring to the role:From Novartis... Read more ...

Research Tech I - La Jolla Institute for Immunology - San Diego, CA

This position requires a 2 to 5 -year commitment. A full-time position for a research technician is immediately available in the Division of Vaccine Discovery...From La Jolla... Read more ...

Research Tech I - La Jolla Institute for Immunology - San Diego, CA

This position requires a 2 to 5 -year commitment. A full-time position for a research technician is immediately available in the Division of Vaccine Discovery...From La Jolla... Read more ...

Commonly used antibiotic shows promise for combating Zika infections

Researchers used a variety of advanced drug screening techniques to test out more than 10,000 compounds in search of a cure. To their surprise, they found that the widely used... Read more ...

CRISPRi screens reveal sources of metabolic robustness in E. coli

Metabolic robustness, the ability of a metabolic system to buffer changes in its environment, is not always a welcome feature for microbiologists: it interferes with metabolic... Read more ...

Enzymatic photocaging for the study of gene regulation through DNA methylation

The addition and removal of methyl groups on DNA plays an important role in gene regulation. In order to study these mechanisms more precisely, a team has developed a new... Read more ...

Greater glider species triple

Researchers analyzed the genetic make-up of the greater glider - a possum-sized marsupial that can glide up to 100 meters. The team confirmed a long-held theory that the... Read more ...

Members of Congress Finding Agreement on a Tech Antitrust Agenda

House Democrats and Republicans are finding common ground on a set of principles for countering tech monopolies that they believe could drive a bipartisan push in the new... Read more ...

Chemist - GenMark Diagnostics - Carlsbad, CA

Document all work according to GLP and GMP. Chemist in the efforts to manufacture custom oligonucleotides for the assay development teams and production.From GenMark... Read more ...

Can we harness a plant's ability to synthesize medicinal compounds?

Anthraquinones are a class of naturally occurring compounds prized for their medicinal properties, as well as for other applications, including ecologically friendly dyes... Read more ...