Computers

Computational design of G Protein-Coupled Receptor allosteric signal transductions

8 monthes ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 02 December 2019; doi:10.1038/s41589-019-0407-2 A computational approach for designing GPCRs with new signaling functions including allosteric signaling properties yielded D2 receptor variants with predictable G-protein signaling responses, some with enhanced potency and responses to dopamine.
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Guided nuclear exploration increases CTCF target search efficiency

8 monthes ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 02 December 2019; doi:10.1038/s41589-019-0422-3 Single-particle tracking and mathematical modeling methods reveal the searching mechanism of CTCF for its cognate sites on DNA. An RNA-binding region in CTCF mediates its trapping in small zones and increases its target search efficiency.
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Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development

8 monthes ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 02 December 2019; doi:10.1038/s41589-019-0415-2 The cellular stability of an oncogenic factor, AIMP2-DX2, is increased via association with HSP70. Interference with this interaction by a small-molecule compound promotes ubiquitin-mediated degradation of AIMP2-DX2 and reduces cancer cell growth.
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Resilient living materials built by printing bacterial spores

8 monthes ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 02 December 2019; doi:10.1038/s41589-019-0412-5 3D printing agarose hydrogels embedded with Bacillus subtilis spores produce custom-shaped materials that are resistant to environmental stresses, while the bacteria maintain the ability to germinate on the surface and respond to stimuli.
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Advisory Body Backs MesoBlast Therapy for Transplant Complication

Advisory Body Backs MesoBlast Therapy for Transplant Complication

An FDA advisory committee Thursday voted 9-1 to recommend that the agency approve a stem cell therapy developed by MesoBlast as a treatment for acute graft-versus-host disease... Read more ...

CureVac's IPO Hauls In $213M as Key mRNA COVID-19 Vaccine Test Nears

CureVac's IPO Hauls In $213M as Key mRNA COVID-19 Vaccine Test Nears

CureVac is playing catch-up to its messenger RNA peers in the race to develop a COVID-19 vaccine, but the company contends its technology could offer dosing advantages, and it... Read more ...

Bio Roundup: Seres Soars, MesoBlast Vote, Duchenne Decision & More

Bio Roundup: Seres Soars, MesoBlast Vote, Duchenne Decision & More

The road of drug development is rife with detours and disappointments but Seres Therapeutics showed this week that course corrections can work. Four years after its microbiome... Read more ...

How COVID-19 Arose and Amplified Along the Meat Supply Chain

How COVID-19 Arose and Amplified Along the Meat Supply Chain

Early in this unforgettable year, a wet market in Wuhan, China, emerged as a possible step along the way, if not the place of origin, of the outbreak that would seed the... Read more ...

Global Methane Emissions Soaring, But How Much Was Due to Wetlands?

Global Methane Emissions Soaring, But How Much Was Due to Wetlands?

Infographic published with permission from the authors of “Increasing anthropogenic methane emissions arise equally from agricultural and fossil fuel sources.” (Credit: Jackson... Read more ...

Computer System Assurance: A Paradigm Shift Away from Compliance to Quality

Computer System Assurance: A Paradigm Shift Away from Compliance to Quality

Our Professional Services Written by: Gary E. Ritchie, MS, Senior Validation Engineer Consultant, PSC Biotech Corporation The FDA will release the draft guidance on Computer... Read more ...

Regulation of tumor necrosis superfamily molecules, BAFF and APRIL, in...

Abstract Tumor necrosis factor superfamily molecules are important inflammatory cytokines, which are involved in diverse immunological functions such as B-cell regulation and... Read more ...

Changes of water, sediment, and intestinal bacterial communities in Penaeus...

Abstract More and more studies have revealed a close relationship between gut microbial community and human health. However, the mechanism why changes in gut microflora... Read more ...

ACS BIOL Broadcast Questions and Discussion Link

This Link will be open between 11:30 AM - 12:45 PM for the AM Broadcast Session and 2:30 - 3:45 PM for the PM Broadcast Session each day. These times are Pacific Time. Read more ...

SQMtools: automated processing and visual analysis of 'omics data with R and...

The dramatic decrease in sequencing costs over the last decade has boosted the adoption of high-throughput sequencing applications as a standard tool for the analysis of... Read more ...