Chemical

Chemically informed analyses of metabolomics mass spectrometry data with Qemistree

2 monthes ago | By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00677-3 Qemistree uses fragmentation spectra to predict molecular fingerprints and represent their relationships as a tree, enabling comparison of metabolomics data across different experimental conditions and exploration of chemical diversity in mixtures.
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Ion channels as lipid sensors: from structures to mechanisms

2 monthes ago | By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00693-3 Ion channel structures reveal mechanisms of lipid action, including how channel gating is altered by direct binding of signaling lipids and those within the membrane itself, as well as mechanical and architectural effects of membrane lipids.
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Cell type-selective secretome profiling in vivo

2 monthes ago | By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00698-y A proximity labeling strategy enables enrichment of cell type-selective secretomes in mice by direct biochemical purification of biotinylated polypeptides from blood plasma.
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Defining new chemical space for drug penetration into Gram-negative bacteria

2 monthes ago | By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00674-6 The difficulty of antibiotic discovery posed by the double-membrane cell envelope of Gram-negative bacteria and active drug efflux requires better understanding of bacterial permeability and compound accumulation, and more diverse chemical libraries.
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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes

2 monthes ago | By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00686-2 The authors report PROTAC ternary complex structures involving the E3 ligase cIAP1 and target protein BTK, showing that cooperativity is not always correlated with degradation efficiency.
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The conformational cycle of a prototypical voltage-gated sodium channel

2 monthes ago | By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-0644-4 The conformational cycle of a bacterial voltage-gated sodium channel as it transitions from resting to activated open to inactivated closed states can be constructed from various crystal structure snapshots.
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Delimiting lipids

2 monthes ago | By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00701-6 This themed issue features a collection of articles that explore long-standing questions in the study of lipids and membranes.
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Making use of surplus sugar

2 monthes ago | By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00687-1 Insects have many ways of disabling plant chemical defenses during feeding. Plant phloem feeders use surplus ingested sugar to block the activation of glucosinolate toxins, providing a target for precise resistance breeding.
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