Chemical

Chemically informed analyses of metabolomics mass spectrometry data with Qemistree

2 monthes ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00677-3 Qemistree uses fragmentation spectra to predict molecular fingerprints and represent their relationships as a tree, enabling comparison of metabolomics data across different experimental conditions and exploration of chemical diversity in mixtures.
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Ion channels as lipid sensors: from structures to mechanisms

2 monthes ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00693-3 Ion channel structures reveal mechanisms of lipid action, including how channel gating is altered by direct binding of signaling lipids and those within the membrane itself, as well as mechanical and architectural effects of membrane lipids.
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Cell type-selective secretome profiling in vivo

2 monthes ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00698-y A proximity labeling strategy enables enrichment of cell type-selective secretomes in mice by direct biochemical purification of biotinylated polypeptides from blood plasma.
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Defining new chemical space for drug penetration into Gram-negative bacteria

2 monthes ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00674-6 The difficulty of antibiotic discovery posed by the double-membrane cell envelope of Gram-negative bacteria and active drug efflux requires better understanding of bacterial permeability and compound accumulation, and more diverse chemical libraries.
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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes

2 monthes ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00686-2 The authors report PROTAC ternary complex structures involving the E3 ligase cIAP1 and target protein BTK, showing that cooperativity is not always correlated with degradation efficiency.
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The conformational cycle of a prototypical voltage-gated sodium channel

2 monthes ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-0644-4 The conformational cycle of a bacterial voltage-gated sodium channel as it transitions from resting to activated open to inactivated closed states can be constructed from various crystal structure snapshots.
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Delimiting lipids

2 monthes ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00701-6 This themed issue features a collection of articles that explore long-standing questions in the study of lipids and membranes.
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Making use of surplus sugar

2 monthes ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00687-1 Insects have many ways of disabling plant chemical defenses during feeding. Plant phloem feeders use surplus ingested sugar to block the activation of glucosinolate toxins, providing a target for precise resistance breeding.
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Bond LSC Researchers Named Most Highly Cited for 2020

Bond LSC Researchers Named Most Highly Cited for 2020

Bond Life Sciences Center principal investigators Bing Yang and Ron Mittler are pictured above. | photos by Erica Overfelt, Bond LSC. By Lauren Hines | Bond LSC Building onto... Read more ...

A New Way to Measure Record-Setting Electron Beams

A New Way to Measure Record-Setting Electron Beams

Sam Barber, left, a research scientist at Berkeley Lab's BELLA Center, and Jeroen van Tilborg, a staff scientist at the BELLA Center, hold the active plasma lens, right, and... Read more ...

Researchers Find Cerebrospinal Fluid Boosts Cancer Cell Aggression

Researchers Find Cerebrospinal Fluid Boosts Cancer Cell Aggression

In cell studies, Mayo researchers and collaborators have uncovered why tumor cells from glioblastoma are more aggressive in one part of the brain than in others. In an article... Read more ...

Historical evolution of spheroids and organoids, and possibilities of use in...

Historical evolution of spheroids and organoids, and possibilities of use in life sciences and medicine

Abstract Background An impressive percentage of biomedical advances were achieved through animal research and cell culture investigations. For drug testing and disease... Read more ...

PSC Software™ Announces the Release of Microsoft Office 365 Integration in...

PSC Software™ Announces the Release of Microsoft Office 365 Integration in Adaptive Compliance Engine® Version 3.5.0

Written By: PSC Software Business Development and Marketing Teams PSC Software , a wholly owned subsidiary of PSC Biotech Corporation , is pleased to announce the integration... Read more ...

The Importance of Good Documentation Practices

The Importance of Good Documentation Practices

Written By: Akshaya Mohan, Regulatory Affairs Manager, PSC Biotech® Documentation is a “record” or “evidence” of an event that has happened. In the life-science industry “If it... Read more ...

Genome-editing tool TALEN outperforms CRISPR-Cas9 in tightly packed DNA

Researchers used single-molecule imaging to compare the genome-editing tools CRISPR-Cas9 and TALEN. Their experiments revealed that TALEN is up to five times more efficient... Read more ...

Blocking drug efflux mechanisms facilitate genome engineering process in...

Penicillium funiculosum NCIM1228 is a non-model filamentous fungus that produces high-quality secretome for lignocellulosic biomass saccharification. Despite having desirable... Read more ...

Approaches to genetic tool development for rapid domestication of non-model...

Non-model microorganisms often possess complex phenotypes that could be important for the future of biofuel and chemical production. They have received significant interest the... Read more ...

Design Therapeutics Secures $125 Million in Series B Financing to Advance...

SAN DIEGO--Design Therapeutics Secures $125 Million in Series B Financing to Advance Pipeline of Genomic Medicines for Nucleotide Repeat Expansion Disorders... Read more ...