Computers

Computational design of G Protein-Coupled Receptor allosteric signal transductions

1 month ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 02 December 2019; doi:10.1038/s41589-019-0407-2 A computational approach for designing GPCRs with new signaling functions including allosteric signaling properties yielded D2 receptor variants with predictable G-protein signaling responses, some with enhanced potency and responses to dopamine.
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Guided nuclear exploration increases CTCF target search efficiency

1 month ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 02 December 2019; doi:10.1038/s41589-019-0422-3 Single-particle tracking and mathematical modeling methods reveal the searching mechanism of CTCF for its cognate sites on DNA. An RNA-binding region in CTCF mediates its trapping in small zones and increases its target search efficiency.
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Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development

1 month ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 02 December 2019; doi:10.1038/s41589-019-0415-2 The cellular stability of an oncogenic factor, AIMP2-DX2, is increased via association with HSP70. Interference with this interaction by a small-molecule compound promotes ubiquitin-mediated degradation of AIMP2-DX2 and reduces cancer cell growth.
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Resilient living materials built by printing bacterial spores

1 month ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 02 December 2019; doi:10.1038/s41589-019-0412-5 3D printing agarose hydrogels embedded with Bacillus subtilis spores produce custom-shaped materials that are resistant to environmental stresses, while the bacteria maintain the ability to germinate on the surface and respond to stimuli.
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World Biotechnology Congress 2019

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World Biotechnology Congress 2019

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2nd International Conference on Tissue Science and Regenerative Medicine

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Cancer Drug Developer BioNTech to Buy Neon Therapeutics in $67M Deal

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Mayo Clinic Joins $60M Financing for Biomedical Software Firm nference

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How Breast Cancer Reunited Six High School Friends

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