Biology

Engineering a nicotinamide mononucleotide redox cofactor system for biocatalysis

1 month ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 25 November 2019; doi:10.1038/s41589-019-0402-7 Redesign of a glucose dehydrogenase to use nicotinamide mononucleotide instead of NAD+ enables the development of a noncanonical cofactor system that can be used to support redox chemistries both in vitro and in Escherichia coli.
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Global targeting of functional tyrosines using sulfur-triazole exchange chemistry

1 month ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 25 November 2019; doi:10.1038/s41589-019-0404-5 Sulfur-triazole exchange chemistry is a tunable platform for covalent chemoproteomic probes that selectively target tyrosines, used to identify residues with enhanced nucleophilicity and monitor activation of phosphotyrosine sites.
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Discovery of an antivirulence compound that reverses β -lactam resistance in MRSA

1 month ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 25 November 2019; doi:10.1038/s41589-019-0401-8 A potent inhibitor of the MRSA virulence regulator, GraR, reverses methicillin resistance, inhibits biofilm formation, limits bacterial survival in macrophages and attenuates virulence in vitro, synergizing with cationic antimicrobial peptides.
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A computational framework to explore large-scale biosynthetic diversity

1 month ago   |   By ACS Division of Biological Chemistry

Nature Chemical Biology, Published online: 25 November 2019; doi:10.1038/s41589-019-0400-9 Two bioinformatic tools, BiG-SCAPE and CORASON, enable sequence similarity network and phylogenetic analysis of gene clusters and their families across hundreds of strains and in large datasets, leading to the discovery of new natural products.
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Revolution Medicines Maps Out an IPO to Reach Cancer's Frontiers

Revolution Medicines Maps Out an IPO to Reach Cancer's Frontiers

Cancer research has revealed proteins known to play a role in the disease, but with no known way of stopping what they do. In pharmaceutical parlance, they're “undruggable.”... Read more ...

Bio Roundup: EQRx's Ambitions, Nektar No Vote, New Frazier Fund & More

Bio Roundup: EQRx's Ambitions, Nektar No Vote, New Frazier Fund & More

Perhaps the most talked-about news at the JP Morgan Healthcare Conference this week was a new startup that launched with $200 million and an ambitious claim its first drug... Read more ...

Trending News on Crop Biotech in 2019

Trending News on Crop Biotech in 2019

We summarized the top 10 most trending Crop Biotech Update news shared on social media to give you a glimpse of crop biotech happenings in 2019. Read on and make sure you don't... Read more ...

Cancer Drug Developer BioNTech to Buy Neon Therapeutics in $67M Deal

Cancer Drug Developer BioNTech to Buy Neon Therapeutics in $67M Deal

Neon Therapeutics closed 2019 by curtailing its cancer vaccine programs and laying off 24 percent of its workforce, part of a corporate restructuring aimed at finding a new... Read more ...

Event Announcement: Xcelerating Life Sciences San Diego

Event Announcement: Xcelerating Life Sciences San Diego

We're excited to announce the first in Xconomy's new Xcelerating Life Sciences event series convening local communities of innovators, executives, rising pioneers... Read more ...

Mayo Clinic Joins $60M Financing for Biomedical Software Firm nference

Mayo Clinic Joins $60M Financing for Biomedical Software Firm nference

Startup nference has closed a $60 million Series B financing round to expand the use of its augmented intelligence platform in clinical research and drug development. Mayo... Read more ...

How Breast Cancer Reunited Six High School Friends

How Breast Cancer Reunited Six High School Friends

Four of the six of us from my high school inner circle have had breast cancer over the past two years. And that has me wondering. Did a shared environmental exposure, stamped... Read more ...

Bachem: Validation Engineer II, QA

Bachem: Your Responsibilities The Validation Engineer II fulfills a critical role in GMP operations. This individual must plan and execute validation studies, Vista, CA, US ... Read more ...

AveXis Inc.: Senior Scientist, Molecular Biology

AveXis Inc.: OverviewReady to join a team committed to developing and commercializing gene therapies for patients and families devastated by rare neurological gene San Diego... Read more ...

Mirati Therapeutics: Talent Partner

Mirati Therapeutics: Reporting to the Head of Business, Culture and Talent this role will be partner with C-Level executive(s) and their staff. This role will be responsib San... Read more ...