Animals

A Game-Changing Test for Prion, Alzheimer's, and Parkinson's Diseases is on the Horizon

6 monthes ago   |   By News Center

Ronald Zuckermann and Michael Connolly hold a model of a protein in a beta sheet arrangement. Aggregates of proteins misfolded into this shape are the disease-causing agents in numerous fatal neurodegenerative diseases. The team's peptoid-coated magnetic beads can bind to these aggregates, allowing scientists to detect them in samples of body fluids.
There are currently no effective treatments for prion diseases, a family of fatal neurodegenerative conditions caused by accumulations of misfolded copies of a naturally occurring protein. But now, there is finally an effective way to test...
Read more ...

 

Dysregulation in the Brain Protein Profile of Zebrafish Lacking the Parkinson's Disease-Related Protein DJ-1

Dysregulation in the Brain Protein Profile of Zebrafish Lacking the Parkinson's Disease-Related Protein DJ-1

6 monthes ago   |   By Springer

Abstract
DJ-1 is a protein with a wide range of functions importantly related to redox regulation in the cell. In humans, dysfunction of the PARK7 gene is associated with neurodegeneration and Parkinson's disease. Our objective was to establish a novel DJ-1 knockout zebrafish line and to identify early brain proteome changes, which could be linked to later pathology. The CRISPR-Cas9 method was used to target exon 1 of the park7-/- gene to produce a transgenic DJ-1-deficient zebrafish model of Parkinson's disease. Label-free mass spectrometry was employed to identify altered protein...
Read more ...

 


Search by Tags

   Animals      Nature      Protein      News Release      Top Story      Alzheimer's disease      Health      Medicine      Molecular biology      Molecular Foundry      Parkinson's disease      Transgenic      Genes      Gene      Brain      Neurodegeneration  


World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Webinar: Using SMRT Sequencing to Understand SARS-CoV-2 and the Host Immune...

Webinar: Using SMRT Sequencing to Understand SARS-CoV-2 and the Host Immune Response

As the flurry of research around the SARS-CoV-2 virus continues at an unprecedented pace, scientists are beginning to tackle some of the more complex immunological responses... Read more ...

Regeneron Pays Intellia $100M to Add Hemophilia to CRISPR R&D Pact

Regeneron Pays Intellia $100M to Add Hemophilia to CRISPR R&D Pact

Four years after Regeneron Pharmaceuticals and Intellia Therapeutics began working together to research the use of CRISPR/Cas9 to treat liver diseases, the partners are... Read more ...

Marketing Coordinator - Advin Biotech - Sorrento, CA

Advin Biotech is a growing medical diagnostics company looking for a creative individual skilled in social media engagement;From Advin Biotech - Tue, 02 Jun 2020 08:54:25 GMT... Read more ...

Gene found that causes eyes to wither in cavefish

Mexican cavefish spend their entire lives in the dark. With no need for vision, many of them lost functional eyes. In more than 30 varieties of Mexican cavefish, the eyes stop... Read more ...

AnaptysBio, Inc.: Facilities Manager

AnaptysBio, Inc.: The Facilities Manager plays a key role ensuring all facilities and equipment support the Company's operations. This person oversees the daily operati San... Read more ...

Research Technician I

Position Overview San Diego Biomedical Research Institute has an opportunity immediately available for a full-time, benefits eligible Research Technician I position. The... Read more ...

Now Complete, Telescope Instrument is Poised to Begin Its Search for Answers...

This video contains animations showing how the complex components of the Dark Energy Spectroscopic Instrument, installed on the Mayall Telescope at Kitt Peak National... Read more ...

Your Brain Needs to Be Ready to Remember?

Read more ...

New Biosensor Visualizes Stress in Living Plant Cells in Real Time

Read more ...

104735 Clinical Trials Coordinator

RADIOLOGY Salary commensurate with qualifications and experienceFiling Deadline: Mon 6/15/2020... Read more ...