Animals

A Game-Changing Test for Prion, Alzheimer's, and Parkinson's Diseases is on the Horizon

10 days ago   |   By News Center

Ronald Zuckermann and Michael Connolly hold a model of a protein in a beta sheet arrangement. Aggregates of proteins misfolded into this shape are the disease-causing agents in numerous fatal neurodegenerative diseases. The team's peptoid-coated magnetic beads can bind to these aggregates, allowing scientists to detect them in samples of body fluids.
There are currently no effective treatments for prion diseases, a family of fatal neurodegenerative conditions caused by accumulations of misfolded copies of a naturally occurring protein. But now, there is finally an effective way to test...
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Dysregulation in the Brain Protein Profile of Zebrafish Lacking the Parkinson's Disease-Related Protein DJ-1

Dysregulation in the Brain Protein Profile of Zebrafish Lacking the Parkinson's Disease-Related Protein DJ-1

10 days ago   |   By Springer

Abstract
DJ-1 is a protein with a wide range of functions importantly related to redox regulation in the cell. In humans, dysfunction of the PARK7 gene is associated with neurodegeneration and Parkinson's disease. Our objective was to establish a novel DJ-1 knockout zebrafish line and to identify early brain proteome changes, which could be linked to later pathology. The CRISPR-Cas9 method was used to target exon 1 of the park7-/- gene to produce a transgenic DJ-1-deficient zebrafish model of Parkinson's disease. Label-free mass spectrometry was employed to identify altered protein...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

IAmScience Clayton Kranawetter

IAmScience Clayton Kranawetter

By Mariah Cox | Bond LSC Taking things apart to figure out how they function was a huge part of Clayton Kranawetter's childhood. From dismantling his parents' old computer to... Read more ...

Cellular “Cleaners” More Active in Quiet Brains

Cellular “Cleaners” More Active in Quiet Brains

Like a robot vacuum for your brain, immune cells called microglia survey around and hoover up the neuro-equivalent of crumbs and dirt. But for the first time Mayo researchers... Read more ...

ResTORbio's Respiratory Drug Flunks Phase 3 Test, Shattering Shares

ResTORbio's Respiratory Drug Flunks Phase 3 Test, Shattering Shares

A resTORbio respiratory drug has failed a late-stage test, and the company is stopping further development of the compound for lung infections in elderly patients. In the first... Read more ...

Biotech Roundup: Gottlieb v. Juul, Solid Slumps, Avidity Gets $100M & More

Biotech Roundup: Gottlieb v. Juul, Solid Slumps, Avidity Gets $100M & More

Lung injuries connected to the use of electronic cigarettes have topped 2,000 and killed 40 people, according to the Centers for Disease Control and Prevention. It's still... Read more ...

Daré to Add Microchip-Based Birth Control to Women's Health Portfolio

Daré to Add Microchip-Based Birth Control to Women's Health Portfolio

The list of activities our smartphones can control grows daily. Transfer money? It's simple. Order groceries? That, too. Turn off the bedroom lights? Check. How about... Read more ...

CRISPR‐Cas12a enables efficient biallelic gene targeting in rice

Abstract Harnessing genetic diversity and introducing elite alleles into commercial cultivars has been a major goal in crop breeding programs. Gene targeting , based on the... Read more ...

OmicplotR: visualizing omic datasets as compositions

Differential abundance analysis is widely used with high-throughput sequencing data to compare gene abundance or expression between groups of samples. Many software packages... Read more ...

Identification of urban particulate matter-induced disruption of human...

Exposure to air particulate matter is associated with various diseases in the human respiratory system. To date, most in vitro studies showing cellular responses to PM have... Read more ...

SEQdata-BEACON: a comprehensive database of sequencing performance and...

The sequencing platform BGISEQ-500 is based on DNBSEQ technology and provides high throughput with low costs. This sequencer has been widely used in various areas of scientific... Read more ...

Success tips from women in science, for girls who want to go into science

Learning from mentors, taking chances and showing passion go a long way... Read more ...