Protein

Increased production of periplasmic proteins in Escherichia coli by directed evolution of the translation initiation region

7 hours ago   |   Microbial Cell Factories   |   2 articles

Recombinant proteins are often engineered with an N-terminal signal peptide, which facilitates their secretion to the oxidising environment of the periplasm or the culture...
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Extraction of Recombinant Periplasmic Proteins Under Industrially Relevant Process Conditions: Selectivity and Yield Strongly Depend on Protein Titer and Methodology

9 hours ago   |   Wiley   |   2 articles

Abstract In this work, we attempted to identify a method for the selective extraction of periplasmic endogenously expressed proteins, which is applicable at an industrial...
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Roche Pays $190M to Start RNA Drug Alliance With Arrakis Therapeutics

Roche Pays $190M to Start RNA Drug Alliance With Arrakis Therapeutics

12 hours ago   |   Xconomy

Some diseases have proven difficult to address using conventional tools of drug discovery that target disease-causing proteins. Roche is placing a $190 million bet on Arrakis...
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Principles of RNA processing from analysis of enhanced CLIP maps for 150 RNA binding proteins

21 hours ago   |   Genome Biology

A critical step in uncovering rules of RNA processing is to study the in vivo regulatory networks of RNA binding proteins. Crosslinking and immunoprecipitation methods enable...
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FASPR: an open-source tool for fast and accurate protein side-chain packing

1 day ago   |   Oxford Journals

AbstractMotivationProtein structure and function are essentially determined by how the side-chain atoms interact with each other. Thus, accurate protein side-chain packing is a...
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Recombinant protein production associated growth inhibition results mainly from transcription and not from translation

1 day ago   |   Microbial Cell Factories

Recombinant protein production can be stressful to the host organism. The extent of stress is determined by the specific properties of the recombinant transcript and protein...
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Distinct processing of lncRNAs contributes to non-conserved functions in stem cells

1 day ago   |   Phys

Long noncoding RNAs , which are longer than 200 nucleotides in length and lack protein coding potential, are pervasively transcribed in eukaryotic genomes. It is well...
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Cullgen Announces Publication of Small Molecule BRAF Protein Degraders in Journal of Medicinal Chemistry

1 day ago   |   San Diego Biotechnology

SAN DIEGO--Cullgen Inc., a leading biotechnology company developing small molecule therapeutics based on its proprietary uSMITE™ platform of targeted protein degradation...
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Another protein degradation biotech emerges, with the promise of a new approach from an old hand

1 day ago   |   San Diego Biotechnology

The money keeps pouring in for protein degradation. A field that six years ago had the financial equivalent of tumbleweed is now flush with cash. Last month, a pair of...
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Artificial Fish Swarm Optimization Based Method to Identify Essential Proteins

1 day ago   |   IEEE/ACM   |   2 articles

It is well known that essential proteins play an extremely important role in controlling cellular activities in living organisms. Identifying essential proteins from protein...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Keros Therapeutics Raises $96M in Upsized IPO to Fuel Clinical Tests

Keros Therapeutics Raises $96M in Upsized IPO to Fuel Clinical Tests

The financial markets may remain volatile but Keros Therapeutics managed to raise more money in its public market debut than it had initially planned. Late Tuesday the... Read more ...

Gilead Heightens Inflammatory Disease Focus With Second Genome Microbiome Deal

Gilead Heightens Inflammatory Disease Focus With Second Genome Microbiome Deal

Gilead Sciences has signed an agreement with South San Francisco biotech Second Genome to use its microbiome drug development expertise to advance the compounds it is... Read more ...

Organovo Future Unclear After Shareholders Reject Tarveda Merger

Organovo Future Unclear After Shareholders Reject Tarveda Merger

A planned merger between struggling 3-D “bioprinter” Organovo and Tarveda Therapeutics, a privately held cancer drug developer looking to join the public markets through a... Read more ...

In Battle Against COVID-19 Pandemic, Scientists Turn to PacBio Sequencing

In Battle Against COVID-19 Pandemic, Scientists Turn to PacBio Sequencing

Image by Miroslava Chrienova from Pixabay Our team is proud to announce that PacBio has been working closely with customers to help in the fight against the COVID-19 pandemic... Read more ...

Roche Pays $190M to Start RNA Drug Alliance With Arrakis Therapeutics

Roche Pays $190M to Start RNA Drug Alliance With Arrakis Therapeutics

Some diseases have proven difficult to address using conventional tools of drug discovery that target disease-causing proteins. Roche is placing a $190 million bet on Arrakis... Read more ...

Inovio Begins Experimental COVID-19 Vaccine Tests in Healthy Volunteers

Inovio Begins Experimental COVID-19 Vaccine Tests in Healthy Volunteers

Inovio Pharmaceuticals, one of the biotechs developing a vaccine to prevent COVID-19, has received the FDA's OK to start testing its candidate in healthy volunteers. The... Read more ...

Sage Restructuring Halves Staff, Turns Focus to Failed Depression Drug

Sage Restructuring Halves Staff, Turns Focus to Failed Depression Drug

Sage Therapeutics is cutting workers who sell its only commercialized drug in a corporate reorganization that it says allows it to focus on clinical-stage compounds, including... Read more ...

Creating Consistent Value in Biotech Without Diluting Stakeholders

Creating Consistent Value in Biotech Without Diluting Stakeholders

One of the greatest challenges for pre-commercial biotech companies is consistently generating capital necessary for operating costs and for R&D of new products that provide... Read more ...

Interactive, Online Xcelerating Life Sciences Boston Event Set for May 13

Interactive, Online Xcelerating Life Sciences Boston Event Set for May 13

In the Boston biotech hub, much progress has been made advancing digital health, but significant scientific, technological, financial, and regulatory challenges remain. Join us... Read more ...

Methylation-driven model for analysis of dinucleotide evolution in genomes

CpGs, the major methylation sites in vertebrate genomes, exhibit a high mutation rate from the methylated form of CpG to TpG/CpA and, therefore, influence the evolution of... Read more ...