Metabolic engineering

Comprehensive analysis of metabolic sensitivity of 1,4‐butanediol producing E. coli towards substrate and oxygen availability

7 days ago   |   Wiley   |   2 articles

Abstract Nowadays, chemical production of 1,4‐butanediol is supplemented by biotechnological processes using a genetically modified E. coli strain, which is an industrial...
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Metabolic engineering with ATP-citrate lyase and nitrogen source supplementation improves itaconic acid production in Aspergillus niger

19 days ago   |   Biotechnology for Biofuels

Bio-based production of organic acids promises to be an attractive alternative for the chemicals industry to substitute petrochemicals as building-block chemicals. In recent...
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Development and characterization of a CRISPR/Cas9n-based multiplex genome editing system for Bacillus subtilis

23 days ago   |   Biotechnology for Biofuels

Metabolic engineering has expanded from a focus on designs requiring a small number of genetic modifications to increasingly complex designs driven by advances in multiplex...
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It takes a 'consortium': Researchers develop metabolic engineering technique

1 month ago   |   Phys

For years, scientists have explored ways to alter the cells of microorganisms in efforts to improve how a wide range of products are made-including medicines, fuels, and even...
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Metabolic engineering of Bacillus amyloliquefaciens for enhanced production of S-adenosylmethionine by coupling of an engineered S-adenosylmethionine pathway and the tricarboxylic acid cycle

1 month ago   |   Biotechnology for Biofuels   |   2 articles

S-Adenosylmethionine is a critical cofactor involved in many biochemical reactions. However, the low fermentation titer of SAM in methionine-free medium hampers...
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Inside Front Cover: Biotechnology Journal 9/2019

Inside Front Cover: Biotechnology Journal 9/2019

1 month ago   |   Wiley   |   5 articles

Production of non‐natural polymers by a microorganism developed by systems metabolic engineering strategies. Systems metabolic engineering strategies that integrate systems and...
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Systems Metabolic Engineering Approaches for Rewiring Cells

1 month ago   |   Wiley

Biotechnology Journal, Volume 14, Issue 9, September 2019.
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Metabolic engineering of roseoflavin-overproducing microorganisms

1 month ago   |   Microbial Cell Factories

Roseoflavin, a promising broad-spectrum antibiotic, is naturally produced by the bacteria Streptomyces davaonensis and Streptomyces cinnabarinus. The key enzymes responsible...
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Systems Metabolic Engineering of Escherichia coli Improves Coconversion of Lignocellulose‐Derived Sugars

Systems Metabolic Engineering of Escherichia coli Improves Coconversion of Lignocellulose‐Derived Sugars

2 monthes ago   |   Wiley

Systems metabolic engineering approaches involving computational modeling, adaptive evolution, and genome sequencing can be used to develop novel strategies for optimizing...
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Metabolic engineering of Bacillus megaterium for heparosan biosynthesis using Pasteurella multocida heparosan synthase, PmHS2

2 monthes ago   |   Microbial Cell Factories

Heparosan is the unsulfated precursor of heparin and heparan sulfate and its synthesis is typically the first step in the production of bioengineered heparin. In addition to...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

SeaGen to Seek FDA Nod After Breast Cancer Drug Hits Goals of Key Study

SeaGen to Seek FDA Nod After Breast Cancer Drug Hits Goals of Key Study

An experimental breast cancer drug from Seattle Genetics is headed for FDA review after the company reported a pivotal clinical trial met its main goals. The company has been... Read more ...

Backed by $50M, Verseau Launches to Reprogram Immune Cells Against Cancer

Backed by $50M, Verseau Launches to Reprogram Immune Cells Against Cancer

Cancer therapies that harness the immune system don't work for all patients. Verseau Therapeutics aims to bring cancer immunotherapy to more people by targeting a type of... Read more ...

The secret of classic Belgian beers? Medieval super-yeasts

An international team of scientists led by Prof. Kevin Verstrepen and Prof. Steven Maere has discovered that some of the most renowned classic Belgian beers, including Gueuze... Read more ...

Edible grasshoppers can be modified for better fatty acid composition

It is possible to modify the fatty acid composition of edible grasshoppers by adding essential fatty acids in their feed, new research from the University of Eastern Finland... Read more ...

Manager, Engineering - Bachem - Vista, CA

The company provides a full range of services to the pharma and biotech industries. Handle complete project life cycle from design, planning and implementation...From Bachem... Read more ...

Bayer backs off running Casebia JV, as CRISPR Tx takes over management

Three years after Bayer and gene-editing biotech CRISPR Therapeutics joined forces to launch and run Casebia Therapeutics, the German Pharma is now handing over the full reins... Read more ...

Uncovering the principles behind RNA folding

Using high-throughput next-generation sequencing technology, a researcher found similarities in the folding tendencies among a family of RNA molecules called riboswitches... Read more ...

Listening in to how proteins talk and learning their language

A research team has created a third approach to engineering proteins that uses deep learning to distill the fundamental features of proteins directly from their amino acid... Read more ...

Pinpointing biomolecules with nanometer accuracy

Scientists demonstrate a new approach in fluorescence microscopy that can be used to locate individual biomolecules in 3D space with nanometer-scale precision. Read more ...

How the mouse X and Y chromosomes compete with each other to control offspring

New research presents the first demonstration of a specific difference in sperm function associated with sex ratio skewing. Read more ...