Genes

Composite Kernel Association Test for SNP-set Joint Assessment of Genotype and Genotype-by-treatment Interaction in Pharmacogenetics Studies

43 minutes ago   |   Oxford Journals

AbstractIt is of substantial interest to discover novel genetic markers that influence drug response in order to develop personalized treatment strategies that maximize...
Read more ...

Discovering and interpreting transcriptomic drivers of imaging traits using neural networks

43 minutes ago   |   Oxford Journals

AbstractMotivationCancer heterogeneity is observed at multiple biological levels. To improve our understanding of these differences and their relevance in medicine, approaches...
Read more ...

AveXis Inc.: Scientist I, Cell Line Development

5 hours ago   |   San Diego Biotechnology   |   6 articles

AveXis Inc.: OverviewReady to join a team committed to developing and commercializing gene therapies for patients and families devastated by rare neurological gene San Diego...
Read more ...

GenEpi: gene-based epistasis discovery using machine learning

15 hours ago   |   BMC Bioinformatics

Genome-wide association studies provide a powerful means to identify associations between genetic variants and phenotypes. However, GWAS techniques for detecting epistasis, the...
Read more ...

Pre- and post-sequencing recommendations for functional annotation of human fecal metagenomes

15 hours ago   |   BMC Bioinformatics

Shotgun metagenomes are often assembled prior to annotation of genes which biases the functional capacity of a community towards its most abundant members. For an unbiased...
Read more ...

A variety of changes, including CRISPR/Cas9 mediated deletions, in CENH3 lead to haploid induction on outcrossing

17 hours ago   |   Wiley   |   2 articles

Summary Creating true‐breeding lines is a critical step in plant breeding. Novel, completely homozygous true‐breeding lines can be generated by doubled haploid technology in...
Read more ...

Engineering herbicide‐resistant oilseed rape by CRISPR/Cas9‐mediated cytosine base‐editing

17 hours ago   |   Wiley   |   2 articles

Abstract CRISPR/Cas9‐based base editor technology that enables precise base‐editing has been developed and applied in several plant species, including Arabidopsis, rice, wheat...
Read more ...

Genetic and Evolution Analysis of Extrafloral Nectary in Cotton

17 hours ago   |   Wiley

Summary Extrafloral nectaries are a defense trait that plays important roles in plant‐animal interactions. Gossypium species are characterized by cellular grooves in leaf...
Read more ...

Turning a green alga red: engineering astaxanthin biosynthesis by intragenic pseudogene revival in Chlamydomonas reinhardtii

17 hours ago   |   Wiley

Summary The green alga Chlamydomonas reinhardtii does not synthesize high‐value ketocarotenoids like canthaxanthin and astaxanthin, however, a β‐carotene ketolase can be found...
Read more ...

A Probabilistic Graphical Model for System-Wide Analysis of Gene Regulatory Networks

23 hours ago   |   Oxford Journals

AbstractMotivationThe inference of gene regulatory networks from DNA microarray measurements forms a core element of systems biology-based phenotyping. In the recent past...
Read more ...


Register you to post on BioTech Mag

Free Registration

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

NGM Bio's NASH Drug Shows Promise, Shares Rise on Early Phase 2 Data

NGM Bio's NASH Drug Shows Promise, Shares Rise on Early Phase 2 Data

In what looks to be a transformative year for potential treatments of nonalcoholic steatohepatitis, the liver disease better known as NASH, another biotech has revealed that... Read more ...

Bicycle Therapeutics Lands $30M From Genentech in New Cancer R&D Pact

Bicycle Therapeutics Lands $30M From Genentech in New Cancer R&D Pact

Genentech is the latest company to enter a drug discovery partnership with Bicycle Therapeutics, adding a new alliance in cancer research for the clinical-stage biotech. Under... Read more ...

UK Reveals Plans For ‘Dynamic' Post-Brexit Regulatory System

UK Reveals Plans For ‘Dynamic' Post-Brexit Regulatory System

At the end of the Brexit transition period, the UK will be charting its own course through the often choppy seas of medicines regulation. While it plans to retain the existing... Read more ...

Esperion's FDA-Approved Cholesterol Drug Priced Even Lower Than Expected

Esperion's FDA-Approved Cholesterol Drug Priced Even Lower Than Expected

As Esperion Therapeutics steered its cholesterol-lowering drug through clinical testing and regulatory review, CEO Tim Mayleben did something unusual for a pharmaceutical... Read more ...

Connecting mathematical models to genomes: Joint estimation of model...

AbstractMotivationParameters of mathematical models used in biology may be genotype-specific and regarded as new traits. Therefore, an accurate estimation of these parameters... Read more ...

Discovering and interpreting transcriptomic drivers of imaging traits using...

AbstractMotivationCancer heterogeneity is observed at multiple biological levels. To improve our understanding of these differences and their relevance in medicine, approaches... Read more ...

Rhapsody: Predicting the pathogenicity of human missense variants

AbstractMotivationThe biological effects of human missense variants have been studied experimentally for decades but predicting their effects in clinical molecular diagnostics... Read more ...

Composite Kernel Association Test for SNP-set Joint Assessment of Genotype...

AbstractIt is of substantial interest to discover novel genetic markers that influence drug response in order to develop personalized treatment strategies that maximize... Read more ...

Neurana Pharmaceuticals to Participate in Cowen Health Care Conference

SAN DIEGO, Feb. 26, 2020 /PRNewswire/ - Neurana Pharmaceuticals, Inc., a biotechnology pharmaceutical company focused on the treatment of neuromuscular conditions, today... Read more ...

Organovo Files Definitive Proxy Statement and Sends Letter to Stockholders

SAN DIEGO--Organovo Holdings, Inc. today announced that it has filed definitive proxy materials with the U.S. Securities and Exchange Commission and has mailed these materials... Read more ...