Drugs

Aveo gives up on ficlatuzumab in acute myeloid leukemia, citing COVID-19

25 minutes ago   |   Fierce Biotech

Back in 2012, Aveo announced that its second most advanced asset, ficlatuzumab, had flopped in a midstage cancer test; for years, we heard nothing about this drug.
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Pioneering CNS-focused Clinical Stage Biopharma: VP or Medical Director for CNS Clinical Development

1 day ago   |   San Diego Biotechnology

Competitive: Pioneering CNS-focused Clinical Stage Biopharma: Drug Development-Experienced MD to lead CNS Clinical Trials. San Diego Area ...
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ACC: New owner Novartis presents pooled inclisiran data cutting LDL cholesterol by half

1 day ago   |   Fierce Biotech

A new, late-phase analysis of the cholesterol-lowering inclisiran-a PCSK9 drug picked up by Novartis through its $9.7 billion acquisition of The Medicines Company-showed that...
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QuartataWeb: integrated chemical-protein-pathway mapping for polypharmacology and chemogenomics

1 day ago   |   Oxford Journals

AbstractSummaryQuartataWeb is a user-friendly server developed for polypharmacological and chemogenomics analyses. Users can easily obtain information on experimentally...
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ACC: Bayer and Merck's vericiguat leads off virtual meeting with positive phase 3 heart failure data

2 days ago   |   Fierce Biotech

After teasing positive top-line results last November, a deeper dive into Merck & Co. and Bayer's heart failure drug vericiguat helped kick off this year's scientific meeting...
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Nuclear Receptor Profiling

2 days ago   |   Indigo Biosciences   |   2 articles

INTRODUCTION Nuclear Receptors act as transcription factors that mediate the effects of certain hormones, drugs, and other xenobiotics by modulating the expression of specific...
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Drug-Nutrient Interactions and Nuclear Receptors

2 days ago   |   Indigo Biosciences

INTRODUCTION There are several clinically relevant instances of a food or dietary supplement altering the activity of a pharmaceutical agent. For example, St. John's Wort , a...
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Xenobiotic, Bile Acid, and Cholesterol Transporters

2 days ago   |   Indigo Biosciences

INTRODUCTION Uptake and efflux transporters determine plasma and tissue concentrations of a broad variety of drugs, nutrients, and xenobiotics (1-3). The liver is the primary...
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Equillium Continues Graft-Versus-Host Disease Trial, Pauses 2 Others

Equillium Continues Graft-Versus-Host Disease Trial, Pauses 2 Others

2 days ago   |   Xconomy

Equillium has halted two clinical trials of its lead drug candidate out of an “abundance of caution” related to the coronavirus outbreak but continues to enroll in a third...
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Completely new antibiotic resistance gene has spread unnoticed to several pathogens

2 days ago   |   ScienceDaily

Aminoglycoside antibiotics are critically important for treating several types of infections with multi-resistant bacteria. A completely new resistance gene, which is likely to...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

San Diego Biotech Entrepreneurs, Innovation Lead to “Maturing” Ecosystem

San Diego Biotech Entrepreneurs, Innovation Lead to “Maturing” Ecosystem

The local biotech ecosystem is growing up thanks to its innovative science and collaborative ecosystem, advantages that put it nearly on par with the nation's top life science... Read more ...

Aveo gives up on ficlatuzumab in acute myeloid leukemia, citing COVID-19

Back in 2012, Aveo announced that its second most advanced asset, ficlatuzumab, had flopped in a midstage cancer test; for years, we heard nothing about this drug. Read more ...

ACC: MyoKardia's mavacamten reduces heart stress signs in targeted biomarker...

The former Fierce 15 winner delivered new cardiac biomarker data showing its late-phase mavacamten compound can help improve signs of heart stress and injury in hypertrophic... Read more ...

Comparison of Swabbing Solution Volume and gDNA Extraction Kits on DNA...

Abstract For bacteria sampling studies, various collection methods have been used to identify bacteria. To obtain accurate information about bacteria, high quality samples... Read more ...

Commentary: Reconciling Hygiene and Cleanliness: A New Perspective from...

Abstract Human beings have co-evolved with the microorganisms in our environment for millions of years, and have developed into a symbiosis in a mutually beneficial/defensive... Read more ...

PCR Screening of Enterococcus faecalis  from Mixture of Lactic Acid Bacteria...

Abstract It is very important to rapidly detect the contamination of Enterococcus faecalis in fermented foods such as Korean Kimchi to maintain its freshness since Kimchi is... Read more ...

Difference of Phenotype and Genotype Between Human and Environmental...

Abstract Cholera due to Vibrio cholerae has been spreading worldwide, although the reports focusing on Indonesian V. cholerae are few. In this study, in order to investigate... Read more ...

Lipid Production by Rhodotorula glutinis in Continuous Cultivation with a...

Abstract Lipid accumulation is generally believed to be a partially growth-coupled biochemical process that results in differences in lipid content between different cells. To... Read more ...

Age- and Sex-Linked Bacterial Community Variation and Function Prediction...

Abstract Sweat secretion keeps feet and insoles humid and rich in nutrients, which are the conditions needed to maintain abundant microbial growth. Analyzing the diversity and... Read more ...

A Review on Occurrence of Pesticides in Environment and Current Technologies...

Abstract Pesticides are the chemicals used to prevent plant diseases, weeds, pests and to enhance the quality of the food products. The uniqueness of their chemical structure... Read more ...