Computers

Computational design of G Protein-Coupled Receptor allosteric signal transductions

7 hours ago   |   ACS Division of Biological Chemistry   |   4 articles

Nature Chemical Biology, Published online: 02 December 2019; doi:10.1038/s41589-019-0407-2 A computational approach for designing GPCRs with new signaling functions including...
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WEDeepT3: predicting type III secreted effectors based on word embedding and deep learning

12 hours ago   |   Springer

Abstract Background The type III secreted effectors are one of the indispensable proteins in the growth and reproduction of Gram-negative bacteria. In particular, the...
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Algorithmic approaches to clonal reconstruction in heterogeneous cell populations

13 hours ago   |   Springer

Abstract Background The reconstruction of clonal haplotypes and their evolutionary history in evolving populations is a common problem in both microbial evolutionary biology...
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Novel bioprinter shows potential to speed tissue engineering

1 day ago   |   Phys

The dream of tissue engineering is a computer-controlled manufacturing of complex and functional human tissue for potential organ regeneration or replacement.
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Genome optimization for improvement of maize breeding

1 day ago   |   Springer

Key message We propose a new model to improve maize breeding that incorporates doubled haploid production, genomic selection, and genome optimization. Abstract Breeding 4.0 has...
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Noise-suppressing zeroing neural network for online solving time-varying nonlinear optimization problem: a control-based approach

1 day ago   |   Springer

Abstract Time-varying nonlinear optimization problems with different noises often arise in the fields of scientific and engineering research. Noises are unavoidable in the...
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Facilities Scheduler - BioLegend Inc. - San Diego, CA

1 day ago   |   San Diego Biotechnology   |   2 articles

Two years of BioTech experience. Three years of similar experience including scheduling, data entry, program coordination, extensive computer usage and record...From BioLegend...
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ImPLoc: A multi-instance deep learning model for the prediction of protein subcellular localization based on immunohistochemistry images

2 days ago   |   Oxford Journals

AbstractMotivationThe tissue atlas of the human protein atlas houses immunohistochemistry images visualizing the protein distribution from the tissue level down to the cell...
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Exploring the interaction mechanism of a dicarboxamide fungicide, iprodione with bovine serum albumin

2 days ago   |   Springer

Abstract Binding of iprodione , a dicarboxamide fungicide, to the carrier protein in bovine circulation, bovine serum albumin was characterized with the help of fluorescence...
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An improved random forest-based computational model for predicting novel miRNA-disease associations

3 days ago   |   BMC Bioinformatics   |   2 articles

A large body of evidence shows that miRNA regulates the expression of its target genes at post-transcriptional level and the dysregulation of miRNA is related to many complex...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

IAmScience Mannie Liscum

IAmScience Mannie Liscum

For Mannie Liscum, thinking is a privilege, and his job gives him the chance to be fascinated by human's capacity to conceptualize and learn new things. “It's my goal to use as... Read more ...

3 Takeaways From the Resurrection of Biogen's Alzheimer's Drug

3 Takeaways From the Resurrection of Biogen's Alzheimer's Drug

The name of the experimental drug was heard so frequently in hotel hallways at the conference that it sounded like an incantation: aducanumab, aducanumab, aducanumab... Read more ...

Acadia Looks to Expand Drug Beyond Parkinson's Disease Psychosis

Acadia Looks to Expand Drug Beyond Parkinson's Disease Psychosis

Acadia Pharmaceuticals revealed late-stage clinical data this week that could support bringing its drug for psychosis to a broader group of patients. The Acadia drug... Read more ...

FDA Puts Partial Hold on Tests of Ipsen Drug Acquired in $1B Deal

FDA Puts Partial Hold on Tests of Ipsen Drug Acquired in $1B Deal

Two clinical trials testing an Ipsen drug in rare connective tissue disorders have been placed on partial hold after safety concerns about chronic dosing of the compound... Read more ...

Bio Roundup: Biogen at CTAD, Sage's Stumble, Astellas's $3B Offer & More

Bio Roundup: Biogen at CTAD, Sage's Stumble, Astellas's $3B Offer & More

It's been a roller-coaster year for those hoping for new drugs to treat Alzheimer's disease, a leading cause of death with rising treatment costs and no clear answer yet as to... Read more ...

A Powerhouse of Cancer Research: A View from Florida

A Powerhouse of Cancer Research: A View from Florida

Nearly everyone has been affected by cancer , either through a personal diagnosis or that of a loved one. In the U.S., 1.7 million people are diagnosed each year, and over 15... Read more ...

Biogen Points to Enrollment and Dosing to Explain Alzheimer's Results

Biogen Points to Enrollment and Dosing to Explain Alzheimer's Results

Biogen revealed detailed results from its Alzheimer's trial to a jam-packed room of eager conference attendees this week-and while some described it as a major advance in the... Read more ...

Family with Two Rare Syndromes Reveals Immunity Glitch

Family with Two Rare Syndromes Reveals Immunity Glitch

Members of a three-generation family in France who suffer from widespread infections and fragile skin, joints, bones, and blood vessels share an underlying and unexpected... Read more ...

Application of A KNN‐based Similarity Method to Biopharmaceutical Manufacturing

Abstract Machine learning based similarity analysis is commonly found in many artificial intelligence applications like the one utilized in e‐commerce and digital marketing. In... Read more ...

Scientists detail how chromosomes reorganize after cell division

Researchers have discovered key mechanisms and structural details of a fundamental biological process - how a cell nucleus and its chromosomal material reorganizes itself after... Read more ...