Biology

Researchers turn bacterial cell into biological computer

44 minutes ago   |   Phys

Researchers at the Technion have created a biological computer, constructed within a bacterial cell and capable of monitoring different substances in the environment...
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Rhapsody: Predicting the pathogenicity of human missense variants

2 hours ago   |   Oxford Journals

AbstractMotivationThe biological effects of human missense variants have been studied experimentally for decades but predicting their effects in clinical molecular diagnostics...
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Discovering and interpreting transcriptomic drivers of imaging traits using neural networks

2 hours ago   |   Oxford Journals

AbstractMotivationCancer heterogeneity is observed at multiple biological levels. To improve our understanding of these differences and their relevance in medicine, approaches...
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Connecting mathematical models to genomes: Joint estimation of model parameters and genome-wide marker effects on these parameters

2 hours ago   |   Oxford Journals

AbstractMotivationParameters of mathematical models used in biology may be genotype-specific and regarded as new traits. Therefore, an accurate estimation of these parameters...
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Takeda buys PvP in $330M deal to bag a second celiac drug

3 hours ago   |   Fierce Biotech

Takeda has exercised its option to buy PvP Biologics, adding another celiac disease candidate to its clinical pipeline. The Japanese drugmaker pulled the trigger on the deal...
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A drug discovery platform to identify compounds that inhibit EGFR triple mutants

11 hours ago   |   ACS Division of Biological Chemistry   |   2 articles

Nature Chemical Biology, Published online: 24 February 2020; doi:10.1038/s41589-020-0484-2 A high-throughput small-molecule drug screening platform enabled the detection of...
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Endosome motility defects revealed at super-resolution in live cells using HIDE probes

11 hours ago   |   ACS Division of Biological Chemistry   |   2 articles

Nature Chemical Biology, Published online: 24 February 2020; doi:10.1038/s41589-020-0479-z HIDE probes were developed for long time-lapse imaging of endolysosomes and their...
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Co‐expression of human calreticulin significantly improves the production of HIV gp140 and other viral glycoproteins in plants

19 hours ago   |   Wiley

Summary Plant molecular farming is rapidly gaining traction as a viable alternative to the currently accepted paradigm of producing biologics. While the platform is potentially...
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Levadura Biotechnology Inc. Solidifies Intellectual Property Position

1 day ago   |   San Diego Biotechnology

SAN DIEGO--Today, Levadura Biotechnology Inc., a leader in synthetic biology with a unique feedstock and biocatalysis approach, announced that it has received the International...
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Vaxign-ML: Supervised Machine Learning Reverse Vaccinology Model for Improved Prediction of Bacterial Protective Antigens

1 day ago   |   Oxford Journals   |   2 articles

AbstractMotivationReverse vaccinology is a milestone in rational vaccine design, and machine learning has been applied to enhance the accuracy of RV prediction. However...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

NGM Bio's NASH Drug Shows Promise, Shares Rise on Early Phase 2 Data

NGM Bio's NASH Drug Shows Promise, Shares Rise on Early Phase 2 Data

In what looks to be a transformative year for potential treatments of nonalcoholic steatohepatitis, the liver disease better known as NASH, another biotech has revealed that... Read more ...

Bicycle Therapeutics Lands $30M From Genentech in New Cancer R&D Pact

Bicycle Therapeutics Lands $30M From Genentech in New Cancer R&D Pact

Genentech is the latest company to enter a drug discovery partnership with Bicycle Therapeutics, adding a new alliance in cancer research for the clinical-stage biotech. Under... Read more ...

UK Reveals Plans For ‘Dynamic' Post-Brexit Regulatory System

UK Reveals Plans For ‘Dynamic' Post-Brexit Regulatory System

At the end of the Brexit transition period, the UK will be charting its own course through the often choppy seas of medicines regulation. While it plans to retain the existing... Read more ...

Esperion's FDA-Approved Cholesterol Drug Priced Even Lower Than Expected

Esperion's FDA-Approved Cholesterol Drug Priced Even Lower Than Expected

As Esperion Therapeutics steered its cholesterol-lowering drug through clinical testing and regulatory review, CEO Tim Mayleben did something unusual for a pharmaceutical... Read more ...

How Resident Microbes Restructure Body Chemistry

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Scientists create virus-resistant tomato plants

Researchers of Valencia's Polytechnic University and the Spanish National Research Council have used tools that regulate gene expression in order to produce tomato plants that... Read more ...

Researchers turn bacterial cell into biological computer

Researchers at the Technion have created a biological computer, constructed within a bacterial cell and capable of monitoring different substances in the environment... Read more ...

Connecting mathematical models to genomes: Joint estimation of model...

AbstractMotivationParameters of mathematical models used in biology may be genotype-specific and regarded as new traits. Therefore, an accurate estimation of these parameters... Read more ...

Discovering and interpreting transcriptomic drivers of imaging traits using...

AbstractMotivationCancer heterogeneity is observed at multiple biological levels. To improve our understanding of these differences and their relevance in medicine, approaches... Read more ...

Rhapsody: Predicting the pathogenicity of human missense variants

AbstractMotivationThe biological effects of human missense variants have been studied experimentally for decades but predicting their effects in clinical molecular diagnostics... Read more ...