Antibiotics

Studying dynamics without explicit dynamics: a structure‐based study of the export mechanism by AcrB

10 hours ago   |   Wiley

Abstract RND family proteins are transmembrane proteins identified as large spectrum drug transporters involved in multi‐drug resistance. A prototypical case in this...
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Helicobacter pylori: Perturbation and restoration of gut microbiome

13 days ago   |   Journal of Biosciences

Abstract Alternate remedies with natural products provides unlimited opportunities for new drug development. These can be either as pure compounds or as standardized set of...
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Recombinant bacteriophage LysKB317 endolysin mitigates Lactobacillus infection of corn mash fermentations

14 days ago   |   Biotechnology for Biofuels

Commercial ethanol fermentation facilities traditionally rely on antibiotics for bacterial contamination control. Here we demonstrate an alternative approach to treat...
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An unprecedented discovery of cell fusion

21 days ago   |   ScienceDaily

Understanding how bacteria interact is critical to solving growing problems such as antibiotic resistance, in which infectious bacteria form defenses to thwart the medicines...
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How antibiotics interact

22 days ago   |   ScienceDaily

Understanding bottleneck effects in the translation of bacterial proteins can lead to a more effective combination of antibiotics.
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Structural analysis of the N‐acetyltransferase Eis1 from Mycobacterium abscessus reveals the molecular determinants of its incapacity to modify aminoglycosides

25 days ago   |   Wiley

Abstract Enhanced intracellular survival proteins belonging to the superfamily of the GCN5‐related N‐acetyltransferases play important functions in mycobacterial pathogenesis...
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Effect of dilution on sedimentational separation of bacteria from blood

26 days ago   |   Wiley

Abstract Bacteria must be separated from septic whole blood in preparation for rapid antibiotic susceptibility tests. This work improves upon past work isolating bacteria from...
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The Crystal Structure of AbsH3: a Putative FAD‐dependent Reductase in the Abyssomicin Biosynthesis Pathway

26 days ago   |   Wiley

Abstract Natural products and natural product‐derived compounds have been widely used for pharmaceuticals for many years, and the search for new natural products that may have...
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Structural basis for antibiotic action of the B 1 antivitamin 2′-methoxy-thiamine

28 days ago   |   ACS Division of Biological Chemistry   |   8 articles

Nature Chemical Biology, Published online: 24 August 2020; doi:10.1038/s41589-020-0628-4 Structural and biochemical analysis of E. coli transketolase with 2′-methoxy-thiamine...
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Pollution linked to antibiotic resistance

1 month ago   |   Phys

Antibiotic resistance is an increasing health problem, but new research suggests it is not only caused by the overuse of antibiotics. It's also caused by pollution.
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Berkeley Team Plays Key Role in Analysis of Particle Interactions That...

Berkeley Team Plays Key Role in Analysis of Particle Interactions That Produce Matter From Light

This image shows a reconstruction of a particle event at CERN's ATLAS detector that produced W bosons from photons, which are particles of light. Researchers at the U.S... Read more ...

Tau-Targeting Alzheimer's Drug from AC Immune, Roche Fails in Phase 2

Tau-Targeting Alzheimer's Drug from AC Immune, Roche Fails in Phase 2

An Alzheimer's disease drug from partners AC Immune and Roche has failed a mid-stage clinical trial, adding another compound to the list of experimental therapies that have... Read more ...

Athira CEO Kawas: Alzheimer's Drug Aims for “Recovery of Brain Function”

Athira CEO Kawas: Alzheimer's Drug Aims for “Recovery of Brain Function”

The key to Athira Pharma's approach to Alzheimer's disease is already inside each of us: a repair mechanism that can regenerate damaged neurons. What's needed to begin the... Read more ...

Gene Therapy Firms Seek Clarity on FDA Exclusivity, Orphan Designations

Gene Therapy Firms Seek Clarity on FDA Exclusivity, Orphan Designations

Gene therapy product developers are seeking more clarity from the US Food and Drug Administration on when viral vectors from the same class will be considered sufficiently... Read more ...

Checkmate, Chromosome 8: The First End-to-End Sequence of a Human Autosome

Checkmate, Chromosome 8: The First End-to-End Sequence of a Human Autosome

Even in the field of genomics where new breakthroughs occur every few months, completion of the first-ever fully sequenced human autosome is a momentous achievement. Highly... Read more ...

Senior Analyst/Programmer II - Remote Role

The primary responsibilities of this position will be to lead database or statistical programming activities and provide end to end programming support in planning, specifying... Read more ...

Knockoff Boosted Tree for Model-Free Variable Selection

AbstractMotivationThe recently proposed knockoff filter is a general framework for controlling the false discovery rate when performing variable selection. This powerful new... Read more ...

IsoResolve: Predicting Splice Isoform Functions by Integrating Gene and...

AbstractMotivationHigh resolution annotation of gene functions is a central goal in functional genomics. A single gene may produce multiple isoforms with different functions... Read more ...

Bedtk: Finding Interval Overlap with Implicit Interval Tree

AbstractSummaryWe present bedtk, a new toolkit for manipulating genomic intervals in the BED format. It supports sorting, merging, intersection, subtraction and the calculation... Read more ...

Prioritizing transcriptomic and epigenomic experiments by using an...

AbstractMotivationSuccessful science often involves not only performing experiments well, but also choosing well among many possible experiments. In a hypothesis generation... Read more ...