Calibrating variant-scoring methods for clinical decision making

8 minutes ago   |   Oxford Journals

AbstractIdentifying pathogenic variants and annotating them is a major challenge in human genetics, especially for the non-coding ones. Several tools have been developed and...
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Efficient Multiple Biomedical Events Extraction Via Reinforcement Learning

8 minutes ago   |   Oxford Journals

AbstractMotivationMultiple events extraction from biomedical literature is a challenging task for biomedical community. Usually, biomedical event extraction is modeled as two...
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Devices and techniques used to obtain and analyse 3‐Dimensional cell cultures

14 minutes ago   |   Wiley

Abstract Cell cultures are indispensable for both basic and applied research. Advancements in cell culture and analysis increase their utility for basic research and...
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High‐capacity Multimodal Anion‐exchange Membranes for Polishing of Therapeutic Proteins

14 minutes ago   |   Wiley   |   2 articles

Abstract This contribution reports on a study using Purexa TM ‐MQ multimodal anion‐exchange membranes for protein polishing at elevated solution conductivities. Dynamic binding...
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Identification and Characterization of a Residual Host Cell Protein Hexosaminidase B Associated with N‐glycan Degradation During the Stability Study of a Therapeutic Recombinant Monoclonal Antibody Product

14 minutes ago   |   Wiley   |   2 articles

Abstract Host cell proteins are process‐related impurities derived from host organisms, which need to be controlled to ensure adequate product quality and safety. In this...
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Effect of particle size distribution on filtration performance of cell culture medium

14 minutes ago   |   Wiley   |   2 articles

Abstract Cell culture media used in CHO‐based biologic processes are typically sterile filtered to prevent microbial contamination prior to inoculation. In this study, the...
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Anti‐epithelial cell adhesion molecule RNA aptamer‐conjugated liposomal doxorubicin as an efficient targeted therapy in mice bearing colon carcinoma tumor model

14 minutes ago   |   Wiley

Abstract To overcome the lack of selectivity and nonspecific biodistribution of drugs in the body, targeted delivery of chemotherapeutic agents with aptamers is a very...
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Model‐based workflow for scale‐up of process strategies developed in miniaturized bioreactor systems

14 minutes ago   |   Wiley   |   2 articles

Abstract Miniaturized bioreactor systems are routinely used in the development of mammalian cell culture processes. However, scale‐up of process strategies obtained in MBR‐ to...
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Structure and binding ability of self‐assembled α‐lactalbumin protein nanotubular gels

14 minutes ago   |   Wiley

Abstract Partial hydrolysis of whey‐based α‐lactalbumin with Bacillus licheniformis protease induces the formation of nanotubular structures in the presence of calcium ions by...
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Key switchgrass genes identified, which could mean better biofuels ahead

1 hour ago   |   Phys

Biologists believe they are one step closer to a long-held goal of making a cheap, widely available plant a source for energy and fuel, meaning one of the next big weapons in...
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World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Bond LSC Researchers Named Most Highly Cited for 2020

Bond LSC Researchers Named Most Highly Cited for 2020

Bond Life Sciences Center principal investigators Bing Yang and Ron Mittler are pictured above. | photos by Erica Overfelt, Bond LSC. By Lauren Hines | Bond LSC Building onto... Read more ...

A New Way to Measure Record-Setting Electron Beams

A New Way to Measure Record-Setting Electron Beams

Sam Barber, left, a research scientist at Berkeley Lab's BELLA Center, and Jeroen van Tilborg, a staff scientist at the BELLA Center, hold the active plasma lens, right, and... Read more ...

Researchers Find Cerebrospinal Fluid Boosts Cancer Cell Aggression

Researchers Find Cerebrospinal Fluid Boosts Cancer Cell Aggression

In cell studies, Mayo researchers and collaborators have uncovered why tumor cells from glioblastoma are more aggressive in one part of the brain than in others. In an article... Read more ...

Historical evolution of spheroids and organoids, and possibilities of use in...

Historical evolution of spheroids and organoids, and possibilities of use in life sciences and medicine

Abstract Background An impressive percentage of biomedical advances were achieved through animal research and cell culture investigations. For drug testing and disease... Read more ...

PSC Software™ Announces the Release of Microsoft Office 365 Integration in...

PSC Software™ Announces the Release of Microsoft Office 365 Integration in Adaptive Compliance Engine® Version 3.5.0

Written By: PSC Software Business Development and Marketing Teams PSC Software , a wholly owned subsidiary of PSC Biotech Corporation , is pleased to announce the integration... Read more ...

The Importance of Good Documentation Practices

The Importance of Good Documentation Practices

Written By: Akshaya Mohan, Regulatory Affairs Manager, PSC Biotech® Documentation is a “record” or “evidence” of an event that has happened. In the life-science industry “If it... Read more ...

RNAi-based products: A sustainable alternative to hazardous pesticides

RNAi-based biocontrol is a great alternative to hazardous pesticides and can contribute towards reversing the alarming decline in farmland birds and beneficial insects . Read more ...

Key switchgrass genes identified, which could mean better biofuels ahead

Biologists believe they are one step closer to a long-held goal of making a cheap, widely available plant a source for energy and fuel, meaning one of the next big weapons in... Read more ...

Genome-editing tool TALEN outperforms CRISPR-Cas9 in tightly packed DNA

Researchers used single-molecule imaging to compare the genome-editing tools CRISPR-Cas9 and TALEN. Their experiments revealed that TALEN is up to five times more efficient... Read more ...

Blocking drug efflux mechanisms facilitate genome engineering process in...

Penicillium funiculosum NCIM1228 is a non-model filamentous fungus that produces high-quality secretome for lignocellulosic biomass saccharification. Despite having desirable... Read more ...